Eli Lilly Announces Negative Results of Solanezumab Phase 3 Trial


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Eli Lilly and Company (NYSE: LLY)today announced that the primary endpoints, both cognitive and functional,were not met in either of the two Phase 3, double-blind, placebo-controlledsolanezumab EXPEDITION trials in patients with mild-to-moderate Alzheimer'sdisease. However, a pre-specified secondary analysis of pooled data acrossboth trials showed statistically significant slowing of cognitive decline inthe overall study population of patients with mild-to-moderate Alzheimer'sdisease. In addition, pre-specified secondary subgroup analyses of pooled dataacross both studies showed a statistically significant slowing of cognitivedecline in patients with mild Alzheimer's disease, but not in patients withmoderate Alzheimer's disease.

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