Shire and FDA Agree on Study Proposal to Confirm Midrodrine Benefit

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Shire plc (NASDAQ: SHPGY), announces that it hasreached an agreement with the Center for Drug Evaluation and Researchat the U.S. Food and Drug Administrationto conduct additional clinicaltrials to confirm the clinical benefit of ProAmatine, amedicine approved in 1996 under Subpart Hfor the treatment of symptomatic orthostatic hypotension.

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