Diagnostic Pathology: Molecular Oncology. Edition No. 2 - ResearchAndMarkets.com

The "Diagnostic Pathology: Molecular Oncology. Edition No. 2" book has been added to ResearchAndMarkets.com's offering.

Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies.

Key Topics Covered:

• DP2 Molecular Oncology: Auerbach and Vasef
• Introduction
• Structure of Chromosomes and Nucleic Acids
• DNA Replication, Transcription, and Translation
• Gene Mutations
• Common Techniques for Analysis of Alterations in Chromosomes and DNA
• Cytogenetics and FISH
• Chromosomal Microarray
• Amplification Methods
• DNA High-Resolution Melting Curve Analysis
• Sequencing Technologies
• High-Throughput Methods in Molecular Pathology
• DNA Methylation Analysis
• Molecular Genetic Tests in Hematopoietic Tumors

*BCR-ABL1* Fusion Gene

*PDGFRA*, *PDGFRB*, and *FGFR1* Rearrangements Detection

• PML-RARA Fusion Gene
• Reverse Transcription PCR for Other Myeloid Leukemia Transcripts
• FLT3, NPM1, and CEBPA Mutations
• JAK2 Mutations and Rearrangements
• MPL Mutations
• Calreticulin (CALR) Mutations
• CSF3R Mutations
• SETBP1 Mutations
• KIT Mutations
• IDH1 and IDH2 Mutations
• Other Mutations and Gene Panel Testing in Myeloid Neoplasms
• Immunoglobulin Heavy (IGH) Chain Gene Rearrangements
• T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements
• T-Cell Receptor Beta (TRB) Chain Gene Rearrangements
• Southern Blot Analysis of Antigen Receptor Genes
• EBV-Associated Human Neoplasms
• MYD88 Mutation
• NOTCH1 Mutation
• EZH2 Mutation
• Molecular Genetic Tests in Solid Tumors, Bone and Soft Tissue Tumors, and CNS Tumors
• ALK Gene Rearrangements and Mutations
• FISH for ROS1 Rearrangements
• RET Rearrangements
• FISH for MET Amplifications
• FISH for ERBB2 (HER2) Gene Amplifications
• KRAS Mutations
• BRAF Mutations
• EGFR Mutations
• Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next Generation Sequencing)
• Targeted Hotspot Gene Panel Table
• MGMT Promoter Gene Methylation Assay
• MET Exon 14 Skip Mutations
• NGS Panels for NCI MATCH
• FISH for 1p/19q Deletions
• IDH1 and IDH2 Mutations
• Molecular Basis of Immunotherapy in Cancer
• Molecular Pathology of Myeloid Neoplasms
• Molecular Pathology of Myeloid Neoplasms
• Molecular Work-Up of Myeloid Neoplasms
• Myeloproliferative Neoplasms
• Chronic Myeloid Leukemia, BCR-ABL1 Positive
• Chronic Neutrophilic Leukemia
• Polycythemia Vera
• Primary Myelofibrosis
• Essential Thrombocythemia
• Chronic Eosinophilic Leukemia, NOS
• Mastocytosis
• Myeloproliferative Neoplasms, Unclassifiable
• Mastocytosis
• Myeloid/Lymphoid Neoplasms With PDGFRA Rearrangement
• Myeloid/Lymphoid Neoplasms With PDGFRB Rearrangement
• Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement
• Myeloid/Lymphoid Neoplasms With PCM1-JAK2
• Myelodysplastic Syndrome (MDS)
• Acute Myeloid Leukemia
• Myeloid Sarcoma
• Acute Leukemias of Ambiguous Lineage
• Overview of Ambiguous Lineage Leukemias
• Acute Undifferentiated and Mixed Phenotype Acute Leukemias
• Molecular Pathology of Lymphoid Neoplasms
• Overview of Lymphoid Neoplasms
• Molecular Work-Up of Lymphoid Neoplasms
• Precursor Lymphoid Neoplasms
• B-Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified
• B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities
• B-Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like
• T-Lymphoblastic Leukemia/Lymphoma
• Mature B-Cell Neoplasms
• Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia
• Monoclonal B-Cell Lymphocytosis
• B-Cell Prolymphocytic Leukemia
• Splenic Marginal Zone Lymphoma
• Hairy Cell Leukemia
• Splenic B-Cell Lymphoma/Leukemia, Unclassifiable
• Lymphoplasmacytic Lymphoma
• IgM Monoclonal Gammopathy of Undetermined Significance
• Heavy Chain Disease
• Plasma Cell Myeloma
• Marginal Zone Lymphoma
• Follicular Lymphoma
• Large B-Cell Lymphoma With IRF4 Rearrangement
• Mantle Cell Lymphoma
• Diffuse Large B-Cell Lymphoma
• T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
• Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation
• Burkitt Lymphoma
• High-Grade B-Cell Lymphoma
• Mature T- and NK-Cell Neoplasms
• T-Cell Prolymphocytic Leukemia
• Chronic Lymphoproliferative Disorder of NK Cells
• Aggressive NK-Cell Leukemia
• Extranodal NK-/T-Cell Lymphoma, Nasal Type
• Adult T-Cell Leukemia/Lymphoma
• Intestinal T-Cell Lymphoma
• Hepatosplenic T-Cell Lymphoma
• Subcutaneous Panniculitis-Like T-Cell Lymphoma
• Mycosis Fungoides/Sezary Syndrome
• Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
• Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtypes
• Peripheral T-Cell Lymphoma, Not Otherwise Specified
• Angioimmunoblastic T-Cell Lymphoma
• Anaplastic Large Cell Lymphoma, ALK-Negative
• Anaplastic Large Cell Lymphoma, ALK-Positive
• Breast Implant-Associated Anaplastic Large Cell Lymphoma
• Determination of Clonality in B-, T-, and NK-Cell Neoplasms
• Lymphoma-Associated Chromosomal Translocations
• Molecular Pathology of Dendritic Cell and Histiocytic Neoplasms
• Histiocytic Sarcoma
• Tumors Derived From Langerhans Cells
• Interdigitating Dendritic Cell Tumor
• Interdigitating Dendritic Cell Sarcoma
• Follicular Dendritic Cell Neoplasm
• Fibroblastic Reticular Cell Tumor
• Disseminated Juvenile Xanthogranuloma
• Erdheim-Chester Disease
• Molecular Pathology of Solid Tumors
• Head and Neck, Including Sinonasal Tumors and Salivary Glands
• HPV-Related Squamous Cell Carcinoma
• Head and Neck Mucosal Squamous Cell Carcinoma, Non-HPV-Related
• Important Alterations in Non-HPV-Related Head & Neck SCC
• Translocation-Specific Salivary Gland Tumors
• Nasopharyngeal EBV-Related Squamous Carcinoma
• Other Head and Neck Tumors
• Thyroid
• Lung
• Liver
• Testis
• Kidney
• Bladder
• Breast
• Cervix/Vulva/Vagina
• Uterus
• Ovaries/Fallopian Tube
• Skin
• Preneoplastic Conditions, Skin
• Melanoma
• Squamous Cell Carcinoma, Skin
• Basal Cell Carcinoma, Skin
• Other Skin Conditions
• Bone
• Soft Tissue
• Overview
• Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors
• Liposarcomas
• Muscle Sarcomas
• Intermediate and Malignant Vascular Tumors
• Malignant Peripheral Nerve Sheath Tumor
• Representative Genetic Findings in Bone and Soft Tissue Tumors
• Sarcomas of Uncertain Differentiation
• Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations
• CNS
• High-Grade Astrocytoma
• Low-Grade Astrocytoma
• Pilocytic Astrocytoma
• Oligodendroglioma
• Ependymoma
• Medulloblastoma
• Choroid Plexus Tumors
• Meningioma
• Retinoblastoma
• Quality Assurance and Regulatory Issues
• Federal Agencies and Regulation of Laboratories
• FDA Regulations
• Proficiency Testing and Accreditation

Authors

• Vasef, Mohammad A. Professor of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
• Auerbach, Aaron Staff Pathologist, Department of Hematopathology, The Joint Pathology Center, Bethesda, Maryland.

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