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Diagnostic Pathology: Molecular Oncology. Edition No. 2 - ResearchAndMarkets.com

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The "Diagnostic Pathology: Molecular Oncology. Edition No. 2" book has been added to ResearchAndMarkets.com's offering.

Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies.

Key Topics Covered:

  • DP2 Molecular Oncology: Auerbach and Vasef
  • Introduction
  • Structure of Chromosomes and Nucleic Acids
  • DNA Replication, Transcription, and Translation
  • Gene Mutations
  • Common Techniques for Analysis of Alterations in Chromosomes and DNA
  • Cytogenetics and FISH
  • Chromosomal Microarray
  • Amplification Methods
  • DNA High-Resolution Melting Curve Analysis
  • Sequencing Technologies
  • High-Throughput Methods in Molecular Pathology
  • DNA Methylation Analysis
  • Molecular Genetic Tests in Hematopoietic Tumors

*BCR-ABL1* Fusion Gene

*PDGFRA*, *PDGFRB*, and *FGFR1* Rearrangements Detection

  • PML-RARA Fusion Gene
  • Reverse Transcription PCR for Other Myeloid Leukemia Transcripts
  • FLT3, NPM1, and CEBPA Mutations
  • JAK2 Mutations and Rearrangements
  • MPL Mutations
  • Calreticulin (CALR) Mutations
  • CSF3R Mutations
  • SETBP1 Mutations
  • KIT Mutations
  • IDH1 and IDH2 Mutations
  • Other Mutations and Gene Panel Testing in Myeloid Neoplasms
  • Immunoglobulin Heavy (IGH) Chain Gene Rearrangements
  • T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements
  • T-Cell Receptor Beta (TRB) Chain Gene Rearrangements
  • Southern Blot Analysis of Antigen Receptor Genes
  • EBV-Associated Human Neoplasms
  • MYD88 Mutation
  • NOTCH1 Mutation
  • EZH2 Mutation
  • Molecular Genetic Tests in Solid Tumors, Bone and Soft Tissue Tumors, and CNS Tumors
  • ALK Gene Rearrangements and Mutations
  • FISH for ROS1 Rearrangements
  • RET Rearrangements
  • FISH for MET Amplifications
  • FISH for ERBB2 (HER2) Gene Amplifications
  • KRAS Mutations
  • BRAF Mutations
  • EGFR Mutations
  • Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next Generation Sequencing)
  • Targeted Hotspot Gene Panel Table
  • MGMT Promoter Gene Methylation Assay
  • MET Exon 14 Skip Mutations
  • NGS Panels for NCI MATCH
  • FISH for 1p/19q Deletions
  • IDH1 and IDH2 Mutations
  • Molecular Basis of Immunotherapy in Cancer
  • Molecular Pathology of Myeloid Neoplasms
  • Molecular Pathology of Myeloid Neoplasms
  • Molecular Work-Up of Myeloid Neoplasms
  • Myeloproliferative Neoplasms
  • Chronic Myeloid Leukemia, BCR-ABL1 Positive
  • Chronic Neutrophilic Leukemia
  • Polycythemia Vera
  • Primary Myelofibrosis
  • Essential Thrombocythemia
  • Chronic Eosinophilic Leukemia, NOS
  • Mastocytosis
  • Myeloproliferative Neoplasms, Unclassifiable
  • Mastocytosis
  • Myeloid/Lymphoid Neoplasms With PDGFRA Rearrangement
  • Myeloid/Lymphoid Neoplasms With PDGFRB Rearrangement
  • Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement
  • Myeloid/Lymphoid Neoplasms With PCM1-JAK2
  • Myelodysplastic Syndrome (MDS)
  • Acute Myeloid Leukemia
  • Myeloid Sarcoma
  • Acute Leukemias of Ambiguous Lineage
  • Overview of Ambiguous Lineage Leukemias
  • Acute Undifferentiated and Mixed Phenotype Acute Leukemias
  • Molecular Pathology of Lymphoid Neoplasms
  • Overview of Lymphoid Neoplasms
  • Molecular Work-Up of Lymphoid Neoplasms
  • Precursor Lymphoid Neoplasms
  • B-Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified
  • B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities
  • B-Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like
  • T-Lymphoblastic Leukemia/Lymphoma
  • Mature B-Cell Neoplasms
  • Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia
  • Monoclonal B-Cell Lymphocytosis
  • B-Cell Prolymphocytic Leukemia
  • Splenic Marginal Zone Lymphoma
  • Hairy Cell Leukemia
  • Splenic B-Cell Lymphoma/Leukemia, Unclassifiable
  • Lymphoplasmacytic Lymphoma
  • IgM Monoclonal Gammopathy of Undetermined Significance
  • Heavy Chain Disease
  • Plasma Cell Myeloma
  • Marginal Zone Lymphoma
  • Follicular Lymphoma
  • Large B-Cell Lymphoma With IRF4 Rearrangement
  • Mantle Cell Lymphoma
  • Diffuse Large B-Cell Lymphoma
  • T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
  • Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation
  • Burkitt Lymphoma
  • High-Grade B-Cell Lymphoma
  • Mature T- and NK-Cell Neoplasms
  • T-Cell Prolymphocytic Leukemia
  • Chronic Lymphoproliferative Disorder of NK Cells
  • Aggressive NK-Cell Leukemia
  • Extranodal NK-/T-Cell Lymphoma, Nasal Type
  • Adult T-Cell Leukemia/Lymphoma
  • Intestinal T-Cell Lymphoma
  • Hepatosplenic T-Cell Lymphoma
  • Subcutaneous Panniculitis-Like T-Cell Lymphoma
  • Mycosis Fungoides/Sezary Syndrome
  • Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
  • Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtypes
  • Peripheral T-Cell Lymphoma, Not Otherwise Specified
  • Angioimmunoblastic T-Cell Lymphoma
  • Anaplastic Large Cell Lymphoma, ALK-Negative
  • Anaplastic Large Cell Lymphoma, ALK-Positive
  • Breast Implant-Associated Anaplastic Large Cell Lymphoma
  • Determination of Clonality in B-, T-, and NK-Cell Neoplasms
  • Lymphoma-Associated Chromosomal Translocations
  • Molecular Pathology of Dendritic Cell and Histiocytic Neoplasms
  • Histiocytic Sarcoma
  • Tumors Derived From Langerhans Cells
  • Interdigitating Dendritic Cell Tumor
  • Interdigitating Dendritic Cell Sarcoma
  • Follicular Dendritic Cell Neoplasm
  • Fibroblastic Reticular Cell Tumor
  • Disseminated Juvenile Xanthogranuloma
  • Erdheim-Chester Disease
  • Molecular Pathology of Solid Tumors
  • Head and Neck, Including Sinonasal Tumors and Salivary Glands
  • HPV-Related Squamous Cell Carcinoma
  • Head and Neck Mucosal Squamous Cell Carcinoma, Non-HPV-Related
  • Important Alterations in Non-HPV-Related Head & Neck SCC
  • Translocation-Specific Salivary Gland Tumors
  • Nasopharyngeal EBV-Related Squamous Carcinoma
  • Other Head and Neck Tumors
  • Thyroid
  • Lung
  • Liver
  • Testis
  • Kidney
  • Bladder
  • Breast
  • Cervix/Vulva/Vagina
  • Uterus
  • Ovaries/Fallopian Tube
  • Skin
  • Preneoplastic Conditions, Skin
  • Melanoma
  • Squamous Cell Carcinoma, Skin
  • Basal Cell Carcinoma, Skin
  • Other Skin Conditions
  • Bone
  • Soft Tissue
  • Overview
  • Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors
  • Liposarcomas
  • Muscle Sarcomas
  • Intermediate and Malignant Vascular Tumors
  • Malignant Peripheral Nerve Sheath Tumor
  • Representative Genetic Findings in Bone and Soft Tissue Tumors
  • Sarcomas of Uncertain Differentiation
  • Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations
  • CNS
  • High-Grade Astrocytoma
  • Low-Grade Astrocytoma
  • Pilocytic Astrocytoma
  • Oligodendroglioma
  • Ependymoma
  • Medulloblastoma
  • Choroid Plexus Tumors
  • Meningioma
  • Retinoblastoma
  • Quality Assurance and Regulatory Issues
  • Federal Agencies and Regulation of Laboratories
  • FDA Regulations
  • Proficiency Testing and Accreditation

Authors

  • Vasef, Mohammad A. Professor of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
  • Auerbach, Aaron Staff Pathologist, Department of Hematopathology, The Joint Pathology Center, Bethesda, Maryland.

For more information about this book visit https://www.researchandmarkets.com/r/u5qb9e

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