Market Overview

3M Enhances the Emphaze™ AEX Hybrid Purifier

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New features deliver additional sizes, sterilization/sanitization
compatibility

Achieving high product purity early in the manufacturing process and
improving efficiency and economics is important to biopharmaceutical
manufacturers. Increasing removal of impurities like DNA and HCP during
clarification improves the performance of downstream capture and
polishing steps. The 3M™ Emphaze™ AEX Hybrid Purifier meet these
challenges through reduction of cell debris, DNA and HCP at
clarification to help improve downstream process steps. The new Emphaze
capsules are sterilization/sanitization compatible and can be used
across various aqueous based biopharmaceutical processes, including
vaccine purification. Additionally, the improved Emphaze AEX Hybrid
Purifier products now feature two new laboratory capsules and one
scale-up capsule that allows evaluations at laboratory and scale-up
volumes.

This press release features multimedia. View the full release here:
https://www.businesswire.com/news/home/20180905005283/en/

The 3M™ Emphaze™ AEX Hybrid Purifier (Photo: 3M)

The 3M™ Emphaze™ AEX Hybrid Purifier (Photo: 3M)

"Customer input is critical in evaluating the performance and
effectiveness of any product to maximize performance," said Himanshu
Nivsarkar, Global Marketing Manager, 3M Separation and Purification
Sciences Division. "With the Emphaze AEX Hybrid Purifier, customers
experience benefits in typical monoclonal antibody purification
processes, including nominal 30% HCP and greater than 4 log DNA
reduction. It has a consistent output turbidity (<5 NTU) leading to
potential downsizing of the sterilizing grade membrane and increased
product purity post-protein A. This also reduces turbidity post viral
inactivation/neutralization step leading to a lower impurities load on
the downstream AEX column, thus allowing customers to optimize their
processes."

Emphaze AEX Hybrid Purifier products are synthetic multi-mechanism
single-use purifier products used for biopharmaceutical clarification.
They deliver consistent, high purity clarified process fluid by removing
soluble and insoluble impurities, such as DNA, HCP, and cell debris,
through a combination of chromatographic and size exclusion mechanisms.
Emphaze AEX Hybrid Purifier products combine three unique 3M
technologies — advanced polymer materials, fine fiber nonwovens, and
membranes — to deliver a synthetic clarifying product line containing a
novel anion exchange nonwoven media and a fine particle, reduction
membrane.

For more information, visit 3m.com/bioprocessing

About 3M

At 3M, we apply science in collaborative ways to improve lives daily.
With $32 billion in sales, our 91,000 employees connect with customers
all around the world. Learn more about 3M's creative solutions to the
world's problems at www.3M.com or
on Twitter @3M or @3MNews.

3M and Emphaze are trademarks of 3M Company.

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