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Brain Imaging Study Demonstrates Digital Psychiatric Therapy "Re-Wires" the Brain, Resulting in Improved Attention in Children with ADHD

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Study in Translational Psychiatry suggests promise of durable
non-pharmacologic treatment

ATENTIV, LLC, pioneers in digital therapies for Attention
Deficit/Hyperactivity Disorder (ADHD) and other cognitive
disorders, today announced the publication of a recently completed brain
imaging study using the ATENTIVmynd™ Technology platform. The study
demonstrated physical evidence that the brain can be ‘rewired' or
‘re-normalized' in children with Attention Deficit/Hyperactivity
Disorder (ADHD) who were given digital psychiatric therapy. This
rewiring was associated with an improvement in attention symptoms
consistent with cumulative evidence from 7 prior clinical trials.

The study, entitled "Brain-computer-interface
intervention re-normalizes brain functional
network topology in children with attention deficit/hyperactivity
disorder
", is available online in the peer-reviewed journal Translational
Psychiatry
published by Nature.
The study was funded by the National Medical Research Council in
Singapore. The intervention was co-developed by the Institute for
Infocomm Research, a research institute managed by the Agency for
Science, Technology and Research in Singapore, and ATENTIV, LLC, a
digital psychiatric therapeutic company, which has developed the
intervention into a platform of ATENTIVmynd™ Games.

The brain imaging study, part of a larger randomized, controlled study
of 172 children with ADHD, included 18 boys (mean age 9.00±1.50 years)
who received the game intervention for 8 weeks, and a wait-list control
arm of 11 boys (mean age 9.45±1.29 years) with ADHD who received no
intervention. Resting state functional Magnetic Resonance Imaging (fMRI)
images, along with clinical assessment of ADHD symptoms via the ADHD
Rating Scale-IV (ADHD RS-IV), were obtained at baseline and at 8 weeks.
Regions of the brain with correlated Brain Oxygen Level Dependent (BOLD)
activity were utilized to assess functional connectivity networks (areas
of the brain that work in concert).

The group receiving the game intervention had several positive
statistically significant outcomes compared with the untreated group.
They had reduced local processing (higher efficiency) within the
salience/ventral attention (SVN) network (brain areas involved in
detecting the importance of information). The reduced local processing
in the SVN was correlated with fewer inattentive symptoms (r = 0.39,
p=0.038). They had increased communication between the central executive
network (brain areas involved in orientation to external stimuli) and
the default mode network (brain areas involved in self-related processes
including daydreaming and mind-wandering).

Jonathan Rubin, MD, MBA, Chief Medical Officer of ATENTIV, LLC,
commented, "This study supports prior research that children with ADHD
have brain networks regulating attention that work with reduced
efficiency. After 8 weeks of the game intervention, abnormal brain
networks regulating attention were re-wired, as seen by a change in
brain network connections to a pattern that more closely resembles that
of a developmentally normal brain. These findings add to the promising
body of evidence from seven prior studies in over 300 children with ADHD
using the ATENTIVmynd™ Game intervention which have demonstrated
improvements in ADHD symptoms, reading, math and homework skills without
the use of medication."

Scott Kollins, PhD, Professor of Psychiatry and Behavioral Sciences at
Duke University School of Medicine and Director of the Duke ADHD
Program, who was not involved in the research, stated, "This new imaging
study provides provocative preliminary evidence that changes in
attentional functioning in ADHD patients as a result of treatment with
the ATENTIVmynd™ Game is mediated through neuroplastic processes. These
findings are an important step toward better understanding the
mechanisms underlying novel approaches to treating ADHD."

About ATENTIVmynd™ Games: ATENTIVmynd™ Games comprise a novel,
non-pharmaceutical, digital cognitive training and therapy platform
designed to provide sustained and measurable improvements in attention
and inhibitory control for individuals when delivered in the clinic,
school or home. The intervention product platform, ATENTIVmynd™ Games,
is delivered via action adventure video games in which the player uses
their brain waves, related to their attention state, to control the
speed of an action character while the player is presented with multiple
dynamic challenges that target, measure and teach the underlying
cognitive skills of attention and inhibitory control. The system
leverages a proprietary, non-invasive direct brain-to-computer interface
to measure a user's unique 'cognitive signature' from brain waves
related to their attention state. Initial product applications are
designed to optimize attention skills in elementary and high school
children and adults. The training is conducted in 20 minute sessions for
3-5 days per week over a period of 5-8 weeks for a total of 8 hours of
gameplay.

About ADHD: Attention Deficit/Hyperactivity Disorder affects
about 11% of children. The core observable symptoms are inattention,
impulsivity and hyperactivity. It is a complex condition involving
several interconnected brain regions, it effects all other executive
functions, including memory, abstract reasoning, critical thinking and
decision making. Causes of ADHD include both genetic and environmental
components. Current treatment approaches for ADHD include medication,
psychosocial interventions (behavioral therapy, parent training and
academic accommodations), working memory training and neurofeedback.

About ATENTIV, LLC: ATENTIV, LLC is a digital psychiatric
therapeutic company that develops and markets a platform of digital
therapeutics and services targeted at the prevention and treatment of
childhood developmental disorders, beginning with ADHD. (http://www.atentiv.com;
www.attentiontherapeutics.com)

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