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BioAxone BioSciences Receives Notice of Allowance on Patent for Treatment of Cerebral Cavernous Malformations and Cerebral Aneurysms with Rho Kinase Inhibitors

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Further strengthens BioAxone's patent portfolio for Rho Kinase 2
inhibitors

BioAxone
BioSciences, Inc
., a biotechnology company focused on developing
innovative drugs to treat neurotrauma and neurovascular disorders, today
announced that it has received a Notice of Allowance from the United
States Patent and Trademark Office (USPTO). The notice refers to a key
patent application (US 15/590,815), which will add to the intellectual
property protection for BA-1049,
BioAxone's first in-class, selective Rho kinase 2 (ROCK2) inhibitor, for
use in combating angioma (also called cerebral cavernous malformations
(CCM)). When issued, this patent will cover using BA-1049 specifically
to treat angioma and also the ability to combine this proprietary
compound with other known inhibitors. BA-1049 acts to reverse the loss
of endothelial barrier dysfunction that occurs in vascular disorders of
the central nervous system.

BA-1049 is part of the neurovascular-focused pipeline of Rho kinase 2
inhibitors in development by BioAxone. Rho kinase 2 (ROCK2) is a drug
target that plays a key role in propagating biological signals that
regulate brain endothelial cell barrier function and this enzyme is
frequently overactivated in neurovascular pathologies where barrier
function is compromised. In animal models of stroke, reversing the
overactivation of ROCK2 that occurs in the vasculature restores
endothelial cell barrier function.

"This is important news for BioAxone and further strengthens the IP
portfolio for our catalogue of ROCK2 inhibitors to treat neurovascular
disorders," said Lisa McKerracher, PhD, CEO, BioAxone BioSciences.
"BA-1049 is a promising oral drug candidate for treatment of angioma to
reverse endothelial cell defects that cause symptoms. It is the only new
chemical entity in development to target the growth and leakiness of
cavernous angioma lesions and could be a transformative treatment for
this unmet need."

About BA-1049
BA-1049 is a first-in-class oral inhibitor of
Rho kinase 2 (ROCK2), a kinase that regulates endothelial cell junctions
and the blood brain barrier. It is in development to treat angioma
(cerebral cavernous malformation), a cerebrovascular disease where
thin-walled, leaky capillaries form brain lesions susceptible to
bleeding that predispose patients to a lifetime risk of seizure,
hemorrhagic stroke and other neurological defects. In preclinical
experiments, BA-1049 has shown promise to repair the leaky endothelial
cell barrier and potentially to reverse progression of the disease.

About BioAxone BioSciences
BioAxone BioSciences is a
clinical-stage biotechnology company based in Cambridge, MA, and is
developing innovative drugs to restore neurological function for
patients with spinal cord injuries and neurovascular disorders. The
company also has preclinical programs in glaucoma and aimed at restoring
epithelial barriers in gastrointestinal disorders. BioAxone is led by a
team of scientists renowned for their work on axon regeneration,
diseases involving Rho/ROCK signaling and cell barrier function. For
more information, visit http://www.bioaxonebio.com
and follow the company on Twitter at @BioAxone.

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