Market Overview

Waters UNIFI Mass Spectrometry Data Acquisition Technology Now Compatible with Mass-MetaSite and WebMetabase

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UNIFI's Application Programming Interface Pairs with Leading MS
Metabolite Identification Processing Software/Platform

Waters Corporation (NYSE:WAT) today announced new capabilities that
provide greater data visibility and faster throughput analysis of
metabolites during drug discovery. By integrating UNIFI™
acquired data from the Vion
IMS QTof™
or Xevo™G2
XS
mass spectrometers with Molecular Discovery's Mass-MetaSite
and WebMetabase
processing software, drug metabolism and pharmacokinetics (DMPK)
scientists now have new analysis capabilities across a variety of
molecules.

Waters UNIFI Scientific Information System is the first software
platform to merge LC and high performance MS data (both quadrupole and
time-of-flight) into a single solution that encompasses data
acquisition, processing, visualization, reporting, and configurable
compliance tools within a networked laboratory environment. This is the
first time that the UNIFI Application Programming Interface (API) has
been made accessible to an outside party and signals a larger Waters
initiative to open its UNIFI products to third-party developers,
ensuring flexibility and optimal fit-for-purpose functionality.

"Waters helps our customers accelerate drug discovery and development to
bring life-changing therapeutics to market. Coupling the superiority of
our high resolution, ion mobility spectral data acquisition capabilities
with the industry's leading drug discovery metabolite identification
software allows us to deliver new capabilities for DMPK scientists,"
said Jeff Mazzeo, Vice President of Marketing at Waters.

Mass-MetaSite features automatic peak detection, structure elucidation,
and batch processing – attributes important for high throughput
identification of known and unknown compounds, including those with
complex structures such as cyclic peptides. WebMetabase accommodates a
number of ADME dedicated workflows, such as soft spot analysis,
glutathione reactive metabolite trapping, cytochrome reaction
phenotyping, and species comparison. This integrates processed
metabolite ID information into the broader context of DMPK and the
discovery design-make-test cycle.

"The collaboration with Waters' scientists and developers has opened up
a great opportunity for our clients to have direct access to data
acquired in UNIFI, which has not only enabled HDMSE
processing, but also improved processing quality for other Waters data
sets," said Ismael Zamora, CEO and Scientific Director at Lead Molecular
Design. "The third-party approach implemented by Waters has been a great
way for Molecular Discovery to enhance our software capabilities and
help our clients attain even higher efficiencies in their DMPK
workflows."

About Waters Corporation (www.waters.com)
Waters
Corporation (NYSE:WAT), the world's leading specialty measurement
company, has pioneered chromatography, mass spectrometry, and thermal
analysis innovations serving the life, materials, and food sciences for
nearly 60 years. With approximately 7,000 employees worldwide, Waters
operates directly in 31 countries, including 15 manufacturing
facilities, and with products available in more than 100 countries.

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