Market Overview

Emmaus Life Sciences Announces Support of Sickle Cell Disease Legislation


Bill Aims to Improve Understanding of Health Care System Utilization for
Patients with SCD

Life Sciences, Inc.
(Emmaus), today announced its support of the
Sickle Cell Disease Surveillance, Prevention, and Treatment Act of 2018 (S.
. The legislation seeks to improve the understanding of health
care system utilization patterns of people with sickle cell disease
(SCD) and establish cost-effective practices to improve and extend the
lives of these patients.

On July 25, the Senate Health, Education, Labor, and Pensions (HELP)
Committee unanimously approved S. 2465, the Sickle Cell Disease
Research, Surveillance, Prevention and Treatment Act of 2018. Next, it
will be reviewed by the full Senate.

Sickle cell disease is an inherited blood disorder characterized by the
production of an altered form of hemoglobin which polymerizes and
becomes fibrous, causing red blood cells to become rigid and change form
so they appear sickle shaped instead of soft and rounded. Patients with
sickle cell disease suffer from debilitating episodes of sickle cell
crises, which occur when the rigid, adhesive and inflexible red blood
cells occlude blood vessels. Sickle cell crises cause excruciating
pain as a result of insufficient oxygen being delivered to tissue,
referred to as tissue ischemia, and inflammation. These events may lead
to a variety of other adverse outcomes such as acute chest syndrome that
requires hospitalization. Sickle cell disease is an orphan disease,
affecting approximately 100,000 patients in the U.S. and millions
worldwide, with significant unmet medical needs.

"As a physician who has treated SCD patients for more than twenty years,
I know first-hand the impact of this disease," said Yutaka Niihara, MD,
MPH, CEO and founder of Emmaus Life Sciences. "This condition exacts a
terrible toll on patients, their families and the community in terms of
pain, missing school or work and hospitalizations. We are pleased to see
this legislation and look forward to it being passed."

Juanita Gougis added, "As a patient with sickle cell disease, I am
adding my voice in support of this bill and its recognition of the
importance of a better understanding of the prevalence of SCD and its
associated health implications."

"On July 25, the Senate Health, Education, Labor, and Pensions (HELP)
Committee unanimously approved S. 2465, the Sickle Cell Disease
Research, Surveillance, Prevention and Treatment Act of 2018," said
Beverley Francis-Gibson, president/CEO for the Sickle
Cell Disease Association of America, Inc
. "This is wonderful news,
and we are grateful for the efforts of Senators Tim Scott (R-SC) and
Cory Booker (D-NJ), who introduced the bill. However, we must continue
our collaborative advocacy efforts to address the complexities of sickle
cell disease and to ensure that the bill becomes law."

Endari™ (L-glutamine oral powder), Emmaus' first commercially available
product, was approved in July 2017 by the FDA and was the first
treatment in nearly 20 years for sickle cell disease. Endari has
received Orphan Drug designation in the U.S., and Orphan Medicinal
Product designation in the EU.

On July 18, 2018, Emmaus announced
that the New
England Journal of Medicine
published results of the company's
48-week, phase 3 clinical trial of Endari, which supported the FDA
approval in July 2017.

About Endari™

Endari is indicated to reduce the acute
complications of sickle cell disease in adult and pediatric patients 5
years of age and older.

Important Safety Information
The most common adverse
reactions (incidence >10%) in clinical studies were constipation,
nausea, headache, abdominal pain, cough, pain in extremity, back pain,
and chest pain.

Adverse reactions leading to treatment discontinuation included 1 case
each of hypersplenism, abdominal pain, dyspepsia, burning sensation, and
hot flash.

The safety and efficacy of Endari in pediatric patients with sickle cell
disease younger than 5 years of age has not been established.

For more information, please see full Prescribing Information of Endari

About Emmaus Life Sciences, Inc.
Emmaus Life Sciences, Inc.
is a biopharmaceutical company engaged in the discovery, development and
commercialization of innovative treatments and therapies primarily for
rare and orphan diseases. Its lead product, Endari, demonstrated
positive clinical results in the completed Phase 3 clinical trial for
sickle cell anemia and sickle ß0-thalassemia and has received FDA
approval. Visit:

Forward-Looking Statements
This press release contains
forward-looking statements as that term is defined in the Private
Securities Litigation Reform Act of 1995, regarding the research,
development and potential commercialization of pharmaceutical products.
Such forward-looking statements are based on current expectations and
involve inherent risks and uncertainties, including factors that could
delay, divert or change any of them, and could cause actual outcomes and
results to differ materially from current expectations. Additional risks
and uncertainties are described in reports filed by Emmaus Life
Sciences, Inc., with the U.S. Securities and Exchange Commission,
including its Annual Report on Form 10-K and Quarterly Reports on Form
10-Q. Emmaus is providing this information as of the date of this press
release and does not undertake any obligation to update any
forward-looking statements as a result of new information, future events
or otherwise.

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