Market Overview

In-Vitro Toxicology Market, 2018-2023 by Technology, Method, Products and Services

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In-Vitro Toxicology Market, 2018-2023 by Technology, Method, Products and Services

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DUBLIN, July 26, 2018 /PRNewswire/ --

The "In Vitro Toxicology Market" report has been added to ResearchAndMarkets.com's offering.

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The in vitro toxicity testing markets include methods and technologies used for toxicity testing of pharmaceuticals, cosmetics, chemicals and food ingredients based on biochemical, cellular and tissue-based assays and platforms. Major stake holders of this market include technology platform developers, reagents and labware suppliers, service providers and end-use industry segments that need to comply with regulatory safety data requirements.

The Market by Technology

A major factor that has enabled the growth of the in vitro toxicity testing market is the advancement of various technologies such as cell culture technologies, high throughput technologies, cellular imaging technologies, and toxicogenomics. The advancement in 3D cell culture technologies, which are replacing 2D cell culture technologies, offer an opportunity to develop complex models that are better able to mimic in vivo systems.

The Market by Method

Reducing animal-based toxicity testing is becoming a possibility as public and private funding investments focus on the development of robust in vitro platforms. Cellular and organotypic models and assays are accounting for a large share of the in vitro toxicity market as their ability to predict toxic effects in vivo is improving with technology advancements. Emerging market segments based on various methods for in vitro toxicity testing can be broadly classified into biochemical assays, cell-based assays and ex vivo systems. Significant innovation is happening in the 3D cell culture-based method segment, which can influence the market landscape of in vitro toxicity testing.

The Market by Products and Services

The products and services segments within in vitro toxicity testing markets can be broadly segmented into various assays, services and reagents and labware.

Competitive LandscapeIn Vitro Toxicology profiles many leading and niche players in the market, including:

  • BioIVT Group
  • Cell Biolabs, Inc.
  • Charles River Laboratories International, Inc.
  • CiToxLAB Group
  • Covance Inc.
  • Creative Bioarray
  • Cyprotex Plc (currently under Evotec AG)
  • Enzo Life Sciences, Inc. (subsidiary of Enzo Biochem, Inc.)
  • Eurofins Scientific S.E.
  • Gentronix Limited
  • HemoGenix, Inc.
  • MatTek Corporation
  • MB Research Laboratories
  • MIMETAS B.V.
  • Organovo Holdings, Inc.
  • Thermo Fisher Scientific Inc.
  • TissUse GmbH
  • Xenometrix AG

Key Topics Covered:

1. Executive Summary

2. Introduction
Market Definition and Scope
Markets Covered
Research Methodology

3. Market Overview
Introduction to In Vitro Toxicity Testing
The Concept of 3Rs
The ToxCast and Tox21 Programs, USA
AXLR8 Project, Europe
DB-ALM, Europe
OECD
ICH
International Cooperation on Cosmetics Regulation (ICCR)
International Cooperation on Alternative Test Methods (ICATM)
Regulatory Landscape, USA
Regulatory Landscape, European Union (EU)
Regulatory Landscape, Japan
Regulatory Landscape, China
Regulatory Landscape, India
Regulatory Landscape, South Korea
Industry Trends
Rising Innovation Leading to In Vitro Models Closer to Human Systems
Emergence of Advanced Technology Platform Companies and Long-Term Partnership Business Models
Consolidation of CRO segment in Response to Rising Outsourcing Trends in Pharma Sector
Market Drivers
Rising Focus on Alternative Models for Toxicity Testing
Increasing Demand for Early Toxicology Testing
Ban on Animal Testing in the Cosmetics Industry
Regulations and Large-Scale Initiatives by Governments
Innovation in Cell Culture Technologies
Market Restraints
Reluctance of Regulatory Agencies to Consider Alternative Methods
Technical Challenges to Develop In Vitro Models That Can Mimic In Vivo Complexities
Human Resource Challenges

4. In Vitro Toxicology Testing Market, by Toxicity Endpoints and Tests
Introduction
ADME-Tox
Solution Properties
Absorption and Transport
Metabolism
Drug-Drug Interactions (DDI)
High Throughput ADME Screening
Skin Irritation, Corrosion and Sensitization
Skin Irritation
Skin Corrosion
Skin Sensitization
Genotoxicity
Cytotoxicity
Ocular Toxicity
Ex Vivo Tests
In Vitro tests
Organ Toxicity
Hepatotoxicity
Cardiotoxicity
Nephrotoxicity
Phototoxicity
Dermal Toxicity
Carcinogenicity
Neurotoxicity
Other Toxicity Endpoints and Tests
Endocrine Disruptors
Developmental and Reproductive Toxicity (DART)
Ecotoxicity
Respiratory Toxicity

5. In Vitro Toxicology Testing Market, by Technology
Introduction
Cell Culture Technologies
Primary Cells
Cell Lines
Choosing between Primary and Continuous Cells
Stem Cells
Rising Popularity of 3D Cell Cultures
Recent Innovations in the Cell Culture Technology Segment
High Throughput Technologies
Cellular Imaging Technologies
3D Cellular Imaging
Current Developments in HCS Markets
Toxicogenomics (TGx)

6. In Vitro Toxicology Testing Market, by Industry
Introduction
Pharmaceutical Industry
Cosmetics Industry
Chemical Industry
Others (Food, Medical Devices, etc)
Food industry
Medical Devices

7. In Vitro Toxicology Testing Market, by Method
Introduction
Biochemical Assays
Gene Expression and Protein Secretion Assays
2D Cell-Based Assays
Non-Mammalian Cell-based Assays
Ames Tests
2D Mammalian Cell-based Assays
Sandwich Cultures and Micropatterning
Increasing Role of Stem Cell-based Assays in In Vitro Toxicity Testing
Resurgence of Phenotypic Cell-based Assays in Early Toxicity Testing
Insights on Cell-based Assay Procurement Practices
Impact of Regulation on Cell-based Assay Markets
2D Cell-based Assay Market Trends and Forecasts
3D Cell Culture Assays and Ex Vivo Systems
Assays Based on Organoids
Assays Based on 3D Bioprinting
Organ-on-a-Chip Models

8. In Vitro Toxicology Testing Market, by Products and Services
Introduction
Assays
Bacterial Toxicity Assays
Cell-based ELISA and Western Blots
Enzyme Toxicity Assays
Receptor Binding Assays
Tissue Culture Assays
Other Assays
Reagents and Labware
Consumables for Cell Cultures
Microplates, Readers, etc.
Labware, Instrumentation, and Reagents for HCS
Services

9. In Vitro Toxicology Testing Market, by Region

10. In Vitro Toxicology Testing Company Profiles
BioIVT Group
Cell Biolabs, Inc.
Charles River Laboratories International, Inc.
CiToxLAB Group
Covance Inc.
Creative Bioarray
Cyprotex Plc (currently under Evotec AG)
Enzo Life Sciences, Inc. (subsidiary of Enzo Biochem, Inc.)
Eurofins Scientific S.E.
Gentronix Limited
HemoGenix, Inc.
MatTek Corporation
MB Research Laboratories
MIMETAS B.V.
Organovo Holdings, Inc.
Thermo Fisher Scientific Inc.
TissUse GmbH
Xenometrix AG

11. Company Names & Addresses
Company Names & Addresses
3D Biotek, LLC
3Dynamic Systems Ltd
Absorption Systems
Abzena
Across Barriers GmbH
Admescope Ltd
Agilent Technologies
Albany Molecular Research Inc. (AMRI)
Alcyomics Ltd
AllCells, LLC
Alternative Toxicity Services
American Type Culture Collection (ATCC)
An-eX analytical services ltd
Anthem BioSciences
Applied Genetics Laboratories, Inc.
APSciences
Ascendance Biotechnology (formerly Hepregen Corporation)
AseaCyte Sdn Bhd
Asinex Ltd
Aspect Biosystems
Aurigene Discovery Technologies Limited
AvantiCell
Bio TeSys GmbH
Bioalternatives SAS
BioIVT
Bioneeds India Private Limited
biopta (Group of Reprocell Europe)
Bio-Rad Laboratories, Inc.
BioReliance Corporation
Bioscience Laboratories
BioScreen Testing Services, Inc.
BioSeek Inc.
BioStatus
BioTalentum Ltd
BioTek Instruments, Inc.
Catalent Pharma Solutions
CellSystems Biotechnologie Vertrieb GmbH
Celther Poland
Charles River Laboratories International Inc.
ChemDiv
ChemPartner
ClinWorld (P) Ltd
CN Bio Innovations Limited
Concord Biosciences LLC
Corning
Covance, Inc. (a part of Laboratory Corporation of America Holdings)
Creative Animodel
Creative Bioarray
Creative Biolabs
Crown Bioscience Inc.
Cultex Laboratories GmbH
Cyfuse Biomedical K.K
Cyprotex PLC (a subsidiary of Evotec Ag)
Cytox
Dermal Technology Laboratory Ltd
ebpi (environmental bio-detection products inc)
Empiriko Corporation
Emulate, Inc.
Enmine LLC
Envigo RMS, Inc.
Epithelix Sàrl
Evercyte GmbH
GE Healthcare
Gentronix Limited
GLR Laboratories Pvt Ltd
GVK Biosciences Private Limited
Hìrel Corporation
HCS Pharma
HD Biosciences
Helix3inc
HemoGenix, Inc.
Hutchison Medi Pharma
ImQuest BioSciences
In Vitro International (IVRO)
INDIGO Biosciences, Inc.
InSphero AG
Institute for In Vitro Sciences, Inc. (IIVS)
Intertek
Invitrocue Limited
Jai Research Foundation
Joinn Laboratories
Jubilant Biosys Limited
Kirkstall, Ltd
KIYATEC
LAUS Corp
Life Chemicals USA, Inc.
Lonza Group Ltd
L'Oréal International
Marin Biologic Laboratories
MatTek Corporation
MB Research Laboratories
Medicilon
Merck KGaA
Microbac Laboratories, Inc.
Mimetas B.V.
MR Research Laboratory
Nano3D Biosciences, Inc.
NOF America Corp
Olympus
ORGANOGENIX, Inc.
Organovo Holdings Inc.
Oroxcell SAS
OxSyBio
Pacific BioLabs
PerkinElmer
Pharmaron Beijing Co., Ltd
Promega Corporation
Puracyp, Inc.
Qgel SA
regenHu Ltd
ReproCELL Europe Ltd
RTC - Research Toxicology Centre
Sai Life Science Ltd
Sanofi Pasteur VaxDesign Campus
Sekisui Xeno Tech, LLC
SenzaGen AB
SGS SA
STEMCELL Technologies
Sundia Meditech
Syngene International Ltd
Synthecon
TCG Life Science (Chembiotek)
Thermo Fisher Scientific
TissUse GmbH
Trevigen
Vanta Bioscience Limited
Vimta Labs
Vipragen Biosciences Private Limited
Vitro Biopharma
VitroScreen S.r.L.
Viva Biotech Ltd
Vivo Bio Tech Ltd
Vivotecnia Research
WuXi AppTec
Xenometrix AG
Zyleris Pharmatech, Inc.

12. Glossary

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