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Probiotic with Digestive Enzymes Supplement Demonstrated to Reduce Cancer Chemotherapy Toxicity in Peer Reviewed Publication, according to Daily Body Restore, LLC

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Probiotic with Digestive Enzymes Supplement Demonstrated to Reduce Cancer Chemotherapy Toxicity in Peer Reviewed Publication, according to Daily Body Restore, LLC

PR Newswire

DETROIT, July 25, 2018 /PRNewswire/ -- A published scientific study in the peer-reviewed journal Oncotarget reports that a probiotic with digestive enzymes supplement is effective at reversing chemotherapy- and antibiotic-induced damage to the gut microbiome. 

The gut microbiome is comprised of "good bacteria" that populate the gut.  On a per cell basis, humans have 10-100 times more bacteria in the gut than cells in the whole body.  This large number of bacteria, and the impact they play on our health, has led to the expression that "the microbiome is our second genome1." This raises the possibility that modulating the microbiome to support "good bacteria" is a promising approach for maintaining a functional immune system.

Previous clinical studies have shown that treatment of cancer patients with chemotherapy or antibiotics has adverse effects on the microbiome, resulting in poor responses of patients to treatments and sometimes serious adverse events2,3

The publication demonstrates that a probiotic with digestive enzymes supplement repairs the microbiome after exposure to chemotherapeutic agent, 5-fluorouracil (5-FU), and an antibiotic, vancomycin. The laboratory studies described in the Oncotarget article show that 5-FU and vancomycin induce a state of gut microbiome dysfunction called "dysbiosis", marked by depletion of "good bacteria" and predominance of bacteria that are typically associated with inflammation.  Treatment with the probiotic with digestive enzymes supplement leads to reversal of the pathological alterations caused by chemotherapy and antibiotic treatment.

The publication is available at:

https://doi.org/10.18632/oncotarget.25778

"This study has implemented a very powerful in vitro model of the intestinal microbiome in which to evaluate the effects of the probiotic with digestive enzymes supplement," stated Dr. Massimo Marzorati, founder of ProDigest, the Belgian Company who conducted the in vitro testing of gut dysbiosis used in the publication. "The supplement was able to improve the numbers and activity of the microbial communities that were adversely impacted by the chemotherapeutic agent and the antibiotic."

Dr. Santosh Kesari, MD PhD, oncologist at the John Wayne Cancer Institute & Pacific Neuroscience Institute at Providence Saint John's Health Center, and co-author on the study said the following: "While more studies need to be completed, these data are extremely promising and suggest the possibility of utilizing this probiotic with digestive enzymes supplement in order to reduce the toxicity of chemotherapeutic agents in cancer patients."

This study was a collaboration between Immune Advisors, LLC, Daily Body Restore®, LLC, and John Wayne Cancer Institute & Pacific Neuroscience Institute at Providence Saint John's Health Center. Billionaire philanthropist, John Paul DeJoria, Co-Founder of Paul Mitchell Hair Care Products, stated: "As an investor in Daily Body Restore®, I am very proud of the results and the study speaks for itself."

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

1 Grice et al. The Human Microbiome: Our Second Genome. Annu Rev Genomics Hum Genet. 2012; 13: 151–170. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518434/
2 Routy et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018 Jan 5;359(6371):91-97. http://science.sciencemag.org/content/359/6371/91.long 
3 Alexander et al. Gut microbiota modulation of chemotherapy efficacy and toxicity. Nat Rev Gastroenterol Hepatol. 2017 Jun 14(6):356-365. https://www.nature.com/articles/nrgastro.2017.20

CONTACT: Miranda Pritchett, 954-336-3871

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SOURCE Daily Body Restore, LLC

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