Market Overview

Minomic Announces Completion of Accrual for Clinical Study of Miltuximab® in Prostate, Bladder and Pancreatic Cancers

Share:

No Drug-Related Adverse Effects Found in Patients

Minomic International Ltd (Minomic) is an immuno-oncology company
specializing in therapeutics and diagnostics for solid tumors, including
prostate, bladder and pancreas. The Company today announced that it has
completed enrolment and dosing of all 12 patients in its pioneering
clinical trial of Miltuximab®, a chimeric version of
Minomic's MIL-38 anti-Glypican 1 antibody conjugated to the radioactive
isotope 67Gallium.

The Miltuximab® Trial is a first-in-human study to evaluate
the safety and tumor targeting of the antibody in patients with
metastatic prostate, bladder, and pancreatic cancer. The primary
endpoint of the trial is safety and tolerability of Miltuximab®.
Secondary endpoints include tumor targeting, pharmacokinetics and
dosimetry to determine relative accumulation of Miltuximab®
in different organs.

All patients have now been dosed and we are pleased to report Miltuximab®
was well tolerated with patients reporting no drug related adverse
events. Secondary endpoints will be reported when data analysis is
completed - to date these are progressing well.

Minomic's CEO, Dr Brad Walsh, said, "These results will inform the
future development of Miltuximab® and most importantly the
next step, progression to a Phase 1 trial in Australia. As we
successfully complete each milestone in this process the company's
attractiveness to potential partners is greatly enhanced. "

Dr Walsh added "We are grateful to the principal investigator Prof.
Howard Gurney and his team at Macquarie University Hospital for their
assistance in conducting the Miltuximab® trial and their
dedication to bringing new therapies to cancer patients."

About Minomic

Minomic International Ltd is an Australian immuno-oncology company
specializing in therapeutics and diagnostics for solid tumors, including
prostate, bladder and pancreas.
Australian immuno-oncology company
GlyTherix has licensed Miltuximab® for the targeted treatment
of a number of cancers. At the core of the technology is a protein known
as Glypican-1 (GPC-1).
GPC-1 occurs in many solid tumors such as
prostate, bladder, pancreatic, glioblastoma, esophageal, ovarian and
brain cancers. It is not present in healthy tissue.
The company has
a strong proprietary and Intellectual Property position covering both
Miltuximab®, the antibody and GPC-1, the antigen. This
provides robust and long-term protection for the commercialization of
important new treatments to people with little hope of cure. Minomic has
now completed a ‘First-in-Human' trial of 12 patients using Miltuximab®
with no drug-related adverse events observed. Minomic is interested in
partnerships or collaborations with larger pharmaceutical global
partners.

View Comments and Join the Discussion!