Market Overview

Librede Inc. Receives Patent for Cannabidiolic Acid (CBDA) Production in Yeast

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Librede, a leader in natural cannabinoid biosynthesis, has been granted
a new patent for the production of cannabidiolic acid (CBDA) in
microorganisms. The patent, Production of Cannabidiolic Acid in Yeast,
describes the modification of yeast to produce CBDA from simple
feedstocks such as sugar. CBDA is a naturally occurring cannabinoid
found in hemp and cannabis which is used to produce cannabidiol (CBD).
Cannabidiol has been shown to have a wide range of therapeutic
properties, including treatment of epilepsy, for which a CBD-based
therapeutic has won recent FDA approval. Librede's fermentation-based
cannabinoid production platform has demonstrated that natural CBD can be
produced outside of the cannabis plant using yeast, in a process that is
similar to making beer. Librede is now in the process of continuing
technology development through optimization and scaling for industrial
production in large fermenters. Dr. Anthony Farina, Librede's Chief
Scientific Officer, explains: "We have been building our platform around
the natural biochemistry in the cannabis plant that gives rise to a
diverse set of compounds, with our focus being on therapeutic
applications. Having engineered cannabidiol synthesis in the laboratory,
we are now beginning the process of scaled up production."

Fermentation for the production of high value, complex, natural products
offers a preferred route to synthesis at an industrial scale. Librede's
biosynthetic approach has several potential advantages over
agricultural-based methods including protection from supply volatility,
improved consistency, reduced cost, and lower environmental impact. Dr.
Jason Poulos, CEO of Librede, explains: "The use of fermentation to
produce these compounds represents the future of industrial scale
cannabinoid production. As more cannabinoids are shown to have
therapeutic value, we must find a way to produce these compounds in a
sustainable way. Utilizing the synthetic power of biology allows us
economical access to these compounds while minimizing environmental
impacts. The future of all cannabinoid production may not be large farm
fields but instead compact and highly efficient fermenters."

About Librede:

Librede is a synthetic biology company that uses biologically-based
approaches to produce high value natural products with a focus on
cannabinoids. Librede's patented yeast-based cannabinoid production
platform can provide therapeutic cannabinoids to diverse markets in an
economically and environmentally sustainable way.

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