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Metactive Presents Results from Nonclinical Research Study Treating Peripheral Arteries

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Results Compare the Blockstent Microcatheter™ to Commercially
Available Vascular Plugs and Coils

Metactive
Medical Inc.
(Metactive), a medical device company developing
innovative products for the treatment of neurovascular and peripheral
vascular diseases, announced today that Dr. Kieran Murphy, Professor,
Vice Chair and Director of Research in the Department of Medical Imaging
at the University of Toronto, presented new nonclinical results from
Metactive's peripheral vascular research program at the Society of
Interventional Radiology (SIR) Annual Scientific Meeting.

In a poster titled "Comparison of Blockstent™ Microcatheter with
Amplatzer™ Vascular Plugs and Cook Nester® Embolization Coils
in Canine Model of Acute and Chronic Arterial Occlusion", Dr. Murphy
presented results comparing the use of Metactive's Blockstent
Microcatheter™, a novel over-the-wire embolic device for the occlusion
of peripheral arteries and veins, with commercially available vascular
plugs and coils to occlude axillary and internal thoracic arteries in a
well-accepted model. Results from the study show that the placement of
the Blockstent Microcatheter resulted in immediate and complete
occlusion in all eight treatments. At 4-week follow-up, histology showed
a mean arterial occlusion of 98%. No arteries treated with Amplatzer™
Vascular Plugs or Nester® Coils showed immediate occlusion by
angiography. The average time to achieve complete occlusion was
approximately 30 minutes for the Amplatzer™ Vascular Plugs and
approximately 4 minutes for the Nester® Coils. At 4-week
follow up, arteries treated with the Amplatzer™ Vascular Plugs showed
57% mean occlusion and arteries treated with Nester® Coils
showed 81% mean occlusion, by histology.

"Physicians have long desired a deliverable vascular plug that can be
placed with a high degree of accuracy and provides immediate, complete,
and lasting vessel occlusion with a low risk of migration. These early
results support the potential for the Blockstent Microcatheter to meet
that need," said Dr. Murphy.

The Society of Interventional Radiology (SIR) Annual Scientific Meeting
was held on March 17 - 22, 2018 in Los Angeles.

About Blockstent Microcatheter

The Blockstent Microcatheter is a novel peripheral vascular embolization
device comprising a 3.3 Fr, highly flexible .014" guidewire-compatible
microcatheter delivery system and an inflatable, detachable metallic
balloon that delivers immediate, complete, and lasting vessel occlusion.

About Peripheral Artery and Vein Embolization

More than 400,000 peripheral artery and vein embolization procedures are
performed worldwide each year using coils and vascular plugs. There is a
need for peripheral artery and vein embolization devices that are highly
flexible and deliverable, can be placed with a high degree of precision,
are resistant to migration, and provide immediate, complete, and lasting
artery and vein occlusion.

About Metactive Medical

Metactive is developing innovative new medical devices for the treatment
of neurovascular and peripheral vascular diseases. Metactive's first
products enable precise and immediate occlusion and rapid sealing of
cerebral aneurysms, arteries, and veins using an over-the-wire
microcatheter platform. For more information, please visit www.metactivemedical.com.

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