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Metactive Presents Results from Nonclinical Research Study Treating Carotid Artery Aneurysms

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Metactive
Medical Inc.
(Metactive), a medical device company developing
innovative products for the treatment of neurovascular and peripheral
vascular diseases, announced today that Dr. Kieran Murphy, Professor,
Vice Chair, and Director of Research in the Department of Medical
Imaging at the University of Toronto, presented new nonclinical results
from Metactive's neurovascular research program at the Society of
Interventional Radiology (SIR) Annual Scientific Meeting.

In an oral presentation titled "Treatment of Carotid Artery Terminal
Bifurcation, Complex Bifurcation and Sidewall Aneurysms in Canines with
the Ballstent Microcatheter", Dr. Murphy discussed results from the
treatment of ten aneurysms with the Ballstent Microcatheter™ in
well-accepted nonclinical models of cerebral aneurysm. Six large, narrow
and wide-necked terminal carotid artery bifurcation aneurysms, two
large, wide-necked complex carotid artery bifurcation aneurysms, and two
wide-necked carotid artery sidewall aneurysms were each treated with a
Ballstent and coils. One narrow-necked terminal carotid artery
bifurcation aneurysm was treated with a Ballstent only.

At 4 - 12-week follow-up, nine aneurysms demonstrated 100% aneurysm neck
and sac occlusion by histology. The remaining aneurysm demonstrated 95%
occlusion, with recanalization of a small segment of the aneurysm neck
that had been treated with a single coil during a follow-up procedure.
All aneurysms demonstrated rapid and complete or near-complete
endothelialization of the aneurysm neck, a critical requirement for an
effective and durable treatment of saccular aneurysms. An additional
large, narrow-necked terminal carotid artery bifurcation aneurysm was
treated with 17 commercially available coils alone. This aneurysm did
not show complete occlusion by angiography immediately after treatment
or at four weeks, and histology demonstrated only 67% aneurysm neck
occlusion with recanalization channels extending into the aneurysm sac.

"In this nonclinical study, the Ballstent Microcatheter, when used with
a few coils, delivered rapid and complete occlusion of the neck and sac
of a wide range of aneurysm sizes, shapes and configurations, including
hard to treat large, wide-necked bifurcation and terminal aneurysms,"
said Dr. Murphy. "The study also showed good biocompatibility for the
Ballstent and rapid endothelialization of the aneurysm neck after
treatment. This new device has the potential to be useful for patients
with large aneurysms, aneurysms arising from bifurcations, ruptured
aneurysms, and aneurysms in patients who would benefit from avoiding
long-term anticoagulation."

The Society of Interventional Radiology (SIR) Annual Scientific Meeting
was held March 17 - 22, 2018 in Los Angeles.

About Ballstent Microcatheter

The Ballstent Microcatheter is a novel saccular aneurysm embolization
device comprising a 3.3 Fr, highly flexible .014" guidewire-compatible
microcatheter delivery system and an inflatable, detachable,
intrasaccular metallic balloon that can be used with coils to provide
immediate, complete, and lasting aneurysm occlusion and rapid
endothelialization of the aneurysm neck.

About Cerebral Aneurysm Embolization

More than 80,000 cerebral aneurysm embolization procedures are performed
worldwide each year using coils, flow-diverting stents, intra-saccular
devices, and liquid embolics. There is a need for cerebral aneurysm
embolization devices that are highly flexible and deliverable, can be
placed with a high degree of precision within the aneurysm sac, and
provide immediate, complete, and lasting aneurysm neck and sac occlusion.

About Metactive Medical

Metactive is developing innovative new medical devices for the treatment
of neurovascular and peripheral vascular diseases. Metactive's first
products enable precise and immediate occlusion and rapid sealing of
cerebral aneurysms, arteries, and veins using an over-the-wire
microcatheter platform. For more information, please visit www.metactivemedical.com.

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