Blood markers identify lupus risk, Feinstein Institute researchers find
MANHASSET, N.Y., May 31, 2018
MANHASSET, N.Y., May 31, 2018 /PRNewswire-USNewswire/ -- Feinstein Institute for Medical Research Professor Betty Diamond, MD, and colleagues discovered what they believe can identify a person's risk for lupus by looking at the presence and amount of antibodies and a protein complex in blood. Health care professionals could now feasibly use these markers to anticipate which lupus patients might benefit from early interventions, or might be at risk of an impending flare. These findings are published in the open-access journal Molecular Medicine.
Dr. Diamond and colleagues developed an index that identifies the risk for lupus based on the presence and amount of Immunoglobin G (IgG) and Immunoglobin M (IgM) antibodies and levels of C1q, a protein complex associated with protection from lupus, in blood serum. To compare potential biomarkers of lupus, or systematic lupus erythematosus (SLE), among women with different SLE risks, the authors analyzed blood serum samples from five cohorts: 40 Malian (West African) women with a history of malaria infection (MAL), 51 African American lupus patients (SLE), 80 healthy African American women (AAHC), 98 unaffected sisters of lupus patients (SIS), and 16 Caucasian healthy controls (CHC).
"We have been curious about why individuals of West African descent have a higher prevalence of lupus," said Dr. Diamond, the corresponding author of the paper. "A better understanding about the risk of lupus and why it differs between populations could help us better treat or even prevent people from getting the condition."
Feinstein Institute researchers found that the risk index they studied was highest in SLE patients; second highest in unaffected sisters of SLE patients; third highest in healthy African-American women and lowest in healthy Caucasian women and malaria-exposed West African women. From this, they can confirm known lupus risk as well as their hypothesis that high levels of IgG, low levels of IgM (and the resulting high IgG to IgM ratio) and low levels of C1q predispose to lupus. The results also confirm that exposure to malaria results in increased levels of protective IgM antibodies and C1q, which may delay onset of lupus in genetically predisposed individuals.
"Dr. Diamond's is a recognized leader in lupus research," noted Kevin J. Tracey, president and CEO of the Feinstein Institute. "Now her discovery of blood markers to assess disease risk also gives new insights into early diagnosis and hope for potential therapeutic pathways."
To view Dr. Diamond's Molecular Medicine paper, click here.
About Molecular Medicine
Molecular Medicine is an open access journal publishing recent findings that elucidate disease pathogenesis at the molecular or physiological level, which may lead to the design of specific tools for disease diagnosis, treatment, or prevention. Manuscripts containing material relevant to the genetic, molecular, or cellular basis of key physiologic or disease processes are considered for publication. Manuscripts submitted to Molecular Medicine should describe the implications of the results for human disease and medicine, at a level approachable by our broad audience.
About the Feinstein Institute
The Feinstein Institute for Medical Research is the research arm of Northwell Health, the largest healthcare provider in New York. Home to 50 research laboratories and to clinical research throughout dozens of hospitals and outpatient facilities, the Feinstein Institute includes 4,000 researchers and staff who are making breakthroughs in molecular medicine, genetics, oncology, brain research, mental health, autoimmunity, and bioelectronic medicine – a new field of science that has the potential to revolutionize medicine. For more information about how we empower imagination and pioneer discovery, visit FeinsteinInstitute.org.
Contact: Heather E. Ball Mayer
SOURCE The Feinstein Institute for Medical Research
© 2022 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
Ad Disclosure: The rate information is obtained by Bankrate from the listed institutions. Bankrate cannot guaranty the accuracy or availability of any rates shown above. Institutions may have different rates on their own websites than those posted on Bankrate.com. The listings that appear on this page are from companies from which this website receives compensation, which may impact how, where, and in what order products appear. This table does not include all companies or all available products.
All rates are subject to change without notice and may vary depending on location. These quotes are from banks, thrifts, and credit unions, some of whom have paid for a link to their own Web site where you can find additional information. Those with a paid link are our Advertisers. Those without a paid link are listings we obtain to improve the consumer shopping experience and are not Advertisers. To receive the Bankrate.com rate from an Advertiser, please identify yourself as a Bankrate customer. Bank and thrift deposits are insured by the Federal Deposit Insurance Corp. Credit union deposits are insured by the National Credit Union Administration.
Consumer Satisfaction: Bankrate attempts to verify the accuracy and availability of its Advertisers' terms through its quality assurance process and requires Advertisers to agree to our Terms and Conditions and to adhere to our Quality Control Program. If you believe that you have received an inaccurate quote or are otherwise not satisfied with the services provided to you by the institution you choose, please click here.
Rate collection and criteria: Click here for more information on rate collection and criteria.