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The Medicines Company Announces Chief Financial Officer Transition

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The Medicines Company (NASDAQ:MDCO) today announced the appointment of
Christopher Visioli as Chief Financial Officer and Treasurer of the
Company, effective immediately. Mr. Visioli succeeds William B.
O'Connor, who is retiring from the Company after serving as Chief
Accounting Officer and then Chief Financial Officer for a total of 13
years. Mr. O'Connor will remain with the Company as an advisor through
2018, assisting Mr. Visioli in transition and completing the close-out
of the Company's non-core businesses and products. Mr. Visioli will
report directly to Clive Meanwell, M.D., Ph.D., Chief Executive Officer
of The Medicines Company.

"Chris brings extensive leadership experience and broad operational
expertise developed over a long and successful career at The Medicines
Company," Dr. Meanwell said. "Chris will play an important role as we
continue to successfully execute on our strategic plan. I know that the
Company will benefit from his expertise, insight and experience, and I
and the rest of the Company's Board of Directors look forward to working
with him. In addition, I would like to personally thank Bill for his
contributions to the Company over more than a decade of successful
service. Bill will continue to serve as an advisor as we wind down our
legacy businesses, and I wish him luck in his retirement upon conclusion
of this important work."

Mr. Visioli previously served as Senior Vice President, Financial
Strategy, of the Company from January 2015 to March 2018, and Vice
President, Cardiovascular Care, from January 2013 to December 2014. Mr.
Visioli joined the Company in June 2003 and has served in a variety of
leadership roles in the organization, including finance, business
development, investor relations, strategy, planning, and business
leadership of the Cardiovascular Care business unit. Prior to joining
the Company, Mr. Visioli was a management consultant at Ernst & Young.
Mr. Visioli holds a Bachelor's Degree in electrical engineering from
Cornell University and an M.B.A. from Columbia Business School.

About The Medicines Company

The Medicines Company is a biopharmaceutical company driven by an
overriding purpose - to save lives, alleviate suffering and contribute
to the economics of healthcare. The Company's mission is to create
transformational solutions to address the most pressing healthcare needs
facing patients, physicians and providers in cardiovascular care. The
Company is headquartered in Parsippany, New Jersey.

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