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Centrexion Therapeutics to Present 6-Month Efficacy Data on CNTX-4975 for the Treatment of Chronic Pain Associated with Knee Osteoarthritis at PAINWeek 2017


Centrexion Therapeutics, a company focused on advancing the treatment
of chronic pain with one of the largest exclusively pain-focused
pipelines of non-opioid therapies in active development, today announced
it will present 6-month data from a randomized, double-blind,
placebo-controlled, dose-ranging study assessing the efficacy and safety
of CNTX-4975 for the treatment of moderate to severe chronic knee pain
associated with osteoarthritis, at the 11th Annual PAINWeek
Meeting taking place September 5 – 9, 2017 at The Cosmopolitan of Las
Vegas in Las Vegas, NV.

Full abstracts are available at
Details of the poster presentation are listed below.

Abstract Title (#76): Efficacy and Safety of CNTX-4975 in
Subjects With Moderate to Severe Osteoarthritis Knee Pain: A 24-Week,
Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study
: 6:30-8:30 p.m. PT, Thursday, September 7
Level 3/Gracia 7 at The Cosmopolitan of Las Vegas

About CNTX-4975

CNTX-4975 is based on Centrexion's proprietary STRATI™ technology (Synthetic
TRans cApsaicin ulTra-pure Injection), a
highly potent, ultrapure, synthetic form of trans-capsaicin (a medicine
traditionally derived from the chili plant). CNTX-4975 is designed to be
injected directly into the site of pain to provide rapid onset, large
reduction and long duration of relief from moderate to severe pain
without affecting touch sensibility or position sense.

CNTX-4975 works by selectively targeting the capsaicin receptor (TRPV1)
to rapidly inactivate only the local pain fibers transmitting signals to
the brain. With a short half-life, STRATI® is cleared from the body
within 24 hours. This approach provides pain relief that can last for
months until the ends of the local pain fibers regenerate, while leaving
the rest of the nerve fiber functioning as normal, and without the risks
of toxicities of NSAIDs and injected steroids or the side effects,
including abuse and addiction, associated with opioid treatments.

About Centrexion Therapeutics

Centrexion Therapeutics, Corp. is focused on advancing the treatment
of chronic moderate to severe pain with one of the largest exclusively
pain-focused pipelines of non-opioid, non-addictive therapies in active
development. Centrexion Therapeutics recognizes the needs of over a
quarter of a billion patients living with chronic pain worldwide, and
aims to develop new, safer and more effective therapies that overcome
the limitations and challenges associated with current pain treatments.
Founded by world-renowned leaders in drug development and well-funded by
key investors, Centrexion Therapeutics is building a pain treatment
powerhouse to address the substantial and growing global chronic pain
epidemic. Centrexion Therapeutics has recently relocated from Baltimore,
Md. to Boston, Mass.

For more information about Centrexion, visit

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