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Benzinga's Volume Movers

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Medivation Inc (NASDAQ: MDVN) shares rose 17.92 percent to $44.09. The volume of Medivation shares traded was 487 percent higher than normal. Medivation shares surged amid word of a new report from Bloomberg, saying the company is working with bankers to defend itself against preliminary interest of a takeover. However, Reuters separately reported the company is working with JPMorgan to handle interest from other companies, but said Medivation has no interest in selling itself.

SciClone Pharmaceuticals, Inc. (NASDAQ: SCLN) shares moved up 10.88 percent to $10.72. The volume of SciClone Pharmaceuticals traded was 347 percent higher than normal. S&P Dow Jones Indices also announced that SciClone Pharmaceuticals will replace Affymetrix, Inc. (NASDAQ: AFFX) in the S&P SmallCap 600 index as Affymetrix is set to be acquired by Thermo Fisher Scientific Inc. (NYSE: TMO).

WebMD Health Corp. (NASDAQ: WBMD) shares climbed 3.94 percent to $61.94. The volume of WebMD Health shares traded was 263 percent higher than normal. S&P Dow Jones Indices announced after Wednesday's market close that WebMD Health will replace Sunedison Inc (NYSE: SUNE) within the S&P MidCap 400 index.

Domtar Corp (USA) (NYSE: UFS) surged 5.66 percent to $40.52. The volume of Domtar shares traded was 175 percent higher than normal. Domtar shares have dropped 13.97 percent over the past 52 weeks, while the S&P 500 index has declined 0.15 percent in the same period.

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