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Anavex Announces Positive Dose-Response Data for ANAVEX 2-73 in Alzheimer's Disease Patients


Anavex Life Sciences Corp. (Nasdaq: AVXL) today reported a positive dose-response relationship has been observed in a pre-planned interim analysis of data from the ongoing Phase 2a trial of ANAVEX 2-73 for treatment of mild to moderate Alzheimer's disease.
The change in Mini Mental State Examination score (MMSE-Δ) (MMSE difference recorded for every single study subject at the beginning and the end of the five week period) from baseline to 5 weeks as a function of ANAVEX 2-73 dose was examined using linear regression analysis.  Among 32 patients treated with doses of ANAVEX 2-73 ranging from 3mg to 50mg/day, the MMSE-Δ data showed a positive slope with confidence intervals not including the zero-value, consistent with a dose dependent improvement in MMSE scores over 5 weeks.  The effect was unidirectional and also positive on another pharmacodynamic readout, the ERP-Δ P300 amplitude. The dose-response results were robust to statistical resampling (bootstrap analysis x 10,000 resamples). Analysis of

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