UPDATE: Enzo Biochem Issues Open Letter to Shareholders

Enzo Biochem, Inc.

("Enzo") has issued the below letter to shareholders: December 22, 2015 Dear Fellow Shareholder, Enzo Biochem, Inc. will hold its 2015 Annual Meeting of Shareholders on January 6, 2016. This year's meeting is particularly important, as a small-cap activist investor, Lone Star Value, owning only approximately 1.0% of the Company's outstanding shares, is seeking control of your independent board members. Lone Star, led by its Principal and Founder Jeffrey Eberwein, is a serial short-term activist investor that has demonstrated a track record of value destruction at the expense of shareholders and the companies that it systematically