Market Overview

Benzinga's Top #PreMarket Losers

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bluebird bio Inc (NASDAQ: BLUE) fell 31.02 percent to $57.71 in pre-market trading on mixed sickle cell data results presented at the ASH 2015.

Global Blood Therapeutics Inc (NASDAQ: GBT) shares tumbled 12.42 percent to $40.00 in pre-market trading after the company reported positive GBT440 Phase 1/2 data.

Chipotle Mexican Grill, Inc. (NYSE: CMG) shares dipped 9.04 percent to $510.00 in pre-market trading. Chipotle reported Friday that the recent e Coli incident had an adverse impact on financial and operating results during the fourth quarter. Cowen & Company downgraded Chipotle from Outperform to Market Perform and lowered the price target from $775.00 to $515.00.

Philip Morris International Inc. (NYSE: PM) shares declined 5.24 percent to $85.00 in pre-market trading.

Chesapeake Energy Corporation (NYSE: CHK) shares fell 3.30 percent to $4.40 in pre-market trading.

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