Benzinga's Top #PreMarket Losers

shares tumbled 21.57 percent to $0.80 in pre-market trading after gaining 47.83 percent on Friday. Martin Shkreli in YouTube live stream on Sunday said that Cyclacel Pharmaceuticals stock is worthless.

shares fell 15.73 percent to $9.32 in pre-market trading. Martin Shkreli said that AEterna Zentaris is worthless.

fell 15.16 percent to $2.07 in pre-market trading after jumping 25.77 percent on Friday. Martin Shkreli said that Macrocure is worthless.

shares dipped 8.70 percent to $31.80 in pre-market trading after gaining 30.79 percent on Friday.

shares declined 3.24 percent to $50.80 in pre-market trading. FBR Capital downgraded Lululemon Athletica from Market Perform to Underperform and lowered the price target from $55.00 to $42.00.