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Cotellic in Combination With Zelboraf Helps People With Specific Advanced Melanoma Live Longer Than With Zelboraf Alone

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Genentech, a member of the Roche Group (OTC: RHHBY),
announced Saturday, data from the pivotal coBRIM study, which showed that
Cotellic (cobimetinib) in combination with Zelboraf
(vemurafenib) helped people with BRAF V600E and V600K mutation-positive
unresectable or metastatic melanoma live significantly longer (overall
survival; OS) than with Zelboraf alone. Cotellic plus Zelboraf reduced
the risk of death by 30 percent compared to Zelboraf alone and helped
people live a median of nearly two years (median OS 22.3 months vs. 17.4
months, hazard ratio [HR]=0.70, 95 percent CI: 0.55-0.90, p=0.005). Ongoing
study monitoring did not identify any new safety signals. The final
coBRIM OS results were presented today during the 12th International
Congress of the Society for Melanoma

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