Puma Biotechnology Prices 979K Share Public Offering of Common Stock at $122.50 per Share

Puma Biotechnology, Inc.

, a development stage biopharmaceutical company, announced the pricing of an underwritten public offering of 979,592 shares of its common stock at $122.50 per share. The Company has granted the underwriters for the offering a 30-day option to purchase up to 146,938 additional shares of common stock at the public offering price, less the underwriting discount. The offering is expected to close on or about February 14, 2014. BofA Merrill Lynch, Citigroup and Leerink Partners LLC are acting as joint book-running managers for the offering. Cowen and Company, LLC and UBS Securities LLC are acting as co-managers for the offering. A registration statement on Form S-3 relating to these securities has been filed with the Securities and Exchange Commission and declared effective. The offering of these securities will be made only by means of a written prospectus forming part of the effective registration statement relating to these securities. Copies of the prospectus for this offering may be obtained, when available, by contacting BofA Merrill Lynch, 222 Broadway, New York, NY 10038, Attn: Prospectus Department, email: dg.prospectus_requests@baml.com; Citigroup, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, phone (800) 831-9146; or Leerink Partners LLC, One Federal Street, 37th Floor, Boston, MA 02110, Attn: Syndicate Department, phone: (800) 808-7525. This news release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or other jurisdiction. About Puma Biotechnology Puma Biotechnology, Inc. is a development stage biopharmaceutical company that acquires and develops innovative products for the treatment of various forms of cancer. The Company focuses on in-licensing drug candidates that are undergoing or have already completed initial clinical testing for the treatment of cancer and then seeks to further develop those drug candidates for commercial use. The Company is initially focused on the development of PB272 (oral neratinib), a potent irreversible tyrosine kinase inhibitor, for the treatment of patients with HER2-positive metastatic breast cancer and patients with non-small cell lung cancer, breast cancer and other solid tumors that have a HER2 mutation.