Market Overview

BioCryst Selects Two Plasma Kallikrein Inhibitors for Hereditary Angioedema into Preclinical Development


Pharmaceuticals (NASDAQ: BCRX) today announced that it has
selected two optimized plasma kallikrein inhibitors to advance into
preclinical development as potential once-daily, oral treatments for the
prevention of hereditary angioedema (HAE) attacks.

The second generation discovery program's goals of improving selectivity
and bioavailability compared to BCX4161
were both met, with no effect on prothrombin time at high concentrations
(>50 micromolar), and oral fraction absorbed exceeding 25%. Similar to
BCX4161, these BioCryst discovered compounds demonstrate sub-nanomolar
potency on the isolated enzyme and single digit nanomolar potency in
suppressing kallikrein activity in an ex vivo activated human plasma
kallikrein inhibition (aPKI) assay. Plasma concentrations of each of

See full press release

Posted-In: News Guidance Contracts Management Global


Related Articles (BCRX)

View Comments and Join the Discussion!

Sprague Resources to Acquire Hess' Commercial Fuels Business; Terms Not Disclosed

Kratos Awarded Multi-Million Dollar Command and Control System Products Contract for QF-16 Air Superiority Target