Provectus Receives Novel Synthesis Patent

Provectus Pharmaceuticals, Inc.

, a development-stage oncology and dermatology biopharmaceutical company, has received U.S Patent No. 8,530,675 by the United States Patent and Trademark Office (USPTO), protecting the synthetic process used to produce the small molecule Rose Bengal, the active pharmaceutical ingredient (API) in PV-10, the Company's lead oncology drug candidate. The new patent, entitled, “Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one (Rose Bengal) and Related Xanthenes,” was originally filed on September 17, 2010. The patent details a new process for the manufacture of Rose Bengal and related iodinated xanthenes in high purity, and was allowed in June 2013. The patent covers the process under which pharmaceutical grade Rose