OncoGenex to Initiate Rainier Clinical Trial Evaluating OGX-427 with ABRAXANE plus Gemcitabine

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OncoGenex Pharmaceuticals, Inc.
OGXI
today announced plans for the initiation of the Rainier™ trial, an investigator-sponsored, randomized, placebo-controlled Phase 2 trial evaluating OGX-427 in combination with ABRAXANE® (paclitaxel protein-bound particles for injectable suspension)(albumin-bound) and gemcitabine in patients with previously untreated metastatic pancreatic cancer. Rainier will randomize approximately 130 patients to receive either OGX-427 or placebo in combination with ABRAXANE and gemcitabine therapy. The primary endpoint of the trial will be overall survival, with additional analyses to evaluate progression-free survival (PFS), tumor response rates, safety, tolerability, and the effect of therapy on heat shock protein (Hsp27) levels. "Based on the positive survival results demonstrated by the Phase 3 MPACT (Metastatic Pancreatic Adenocarcinoma Clinical Trial) trial, many patients with advanced pancreatic cancer will undoubtedly receive treatment with gemcitabine plus ABRAXANE in the future. However, survival times remain short for these patients, and we need to continue to explore new strategies to address treatment resistance," stated Andrew H. Ko MD, Associate Professor of Medicine, Division of Hematology/Oncology at the University
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Posted In: NewsGuidanceContractsManagementGlobal
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