AbbVie, Ipsen Terminate Partnerships With Exicure As Bankruptcy Concern Looms

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  • Exicure Inc XCUR announced the termination of its collaboration agreements with AbbVie Inc ABBV and Ipsen BioPharm Limited IPSEY.
  • Through separate agreements with AbbVie and Ipsen, Exicure was collaboratively advancing specified discovery programs in hair loss disorders and rare neurodegenerative disorders, respectively.
  • As a result of this termination, Exicure can develop medicines targeting hair loss disorders, Angelman syndrome independently, and Huntington's disease – while Ipsen retains the right to re-enter into the collaboration with Exicure in Huntington's Disease and Angelman's Syndrome.
  • In 2019, AbbVie partnered with Exicure for $25 million upfront in a hair-loss drug development deal. Two years later, Ipsen had paid $20 million upfront, with milestones worth up to $1 billion, to partner on two neurological programs.
  • In September, Exicure announced restructuring plans and aligned resources to continue exploring strategic alternatives
  • The company will cut its workforce by approximately 66%, expected to complete by Q4 of 2022.
  • It will also cease all R&D activities, including suspending all partnered programs.
  • In its Q3 earnings release, Exicure's management warned of substantial doubt regarding the company's ability to continue as a going concern within one year
  • Price Action: XCUR shares closed at $0.73 on Tuesday.
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