This Diabetes Drug's 'Licensing Opportunity Is Underappreciated,' Analyst Says

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  • Earlier this week, vTv Therapeutics Inc VTVT named a new CEO, Paul Sekhri, and announced the progress with the initiation of pivotal TTP399 trials. 
  • TTP399 is a novel, oral, liver-selective glucokinase activator that has FDA Breakthrough Therapy Designation for type 1 diabetes. 
  • Phase 2 study previously demonstrated approximately 40% reduction of hypoglycemic episodes with once-daily doses of TTP399 compared to placebo. 
  • Also Read: vTv Therapeutics Shares Jump On Equity Investment.
  • Currently, vTv is planning two pivotal, placebo-controlled clinical trials with TTP399 in subjects with T1D (n=1,000), with at least one of the studies expected to treat patients for a year. 
  • HC Wainwright believes TTP399 targets a significant market opportunity given that there are no approved therapies for reducing hypoglycemic episodes. 
  • The analysts estimate approximately 1.6 million people with T1D in the U.S. and about 26 million with T1D globally.
  • Since TPP399 has a benign safety profile, TTP399 could realize more than $1 billion in annual sales as an adjunctive treatment to insulin, using just 10% of T1D patients, HC Wainwright writes.
  • The analyst reiterates the Buy rating and the price target of $6. 
  • Price Action: VTVT shares are down 0.80% at $1.21 on the last check Thursday.
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