Skip to main content

Market Overview

What's Pushing Nano-Cap Biotech DiaMedica's Shares Higher?

What's Pushing Nano-Cap Biotech DiaMedica's Shares Higher?

Shares of the thinly traded nano-cap biotech DiaMedica Therapeutics Inc (NASDAQ: DMAC) were rallying strongly Thursday.

What Happened

DiaMedica announced positive interim results from a Phase 1b study of its DM199, which is being evaluated for moderate-to-severe chronic kidney disease, or CKD.

DM199 is a synthetic form of human serine protease KLK1, which plays a key role in the regulation of diverse psychologic processes such as blood flow, inflammation, fibrosis, oxidative stress and neurogenesis through an increase in the production of nitric oxide, prostacyclin and other anti-inflammatory mediators.

The interim results of the study, which had 28 evaluable patients, showed the drug was safe and well-tolerated, with no drug-related serious adverse events and a pharmacokinetic profile in CKD subjects similar to that of healthy volunteers.

Pharmacokinetics, safety and tolerability were the primary endpoints of the trial.

The study also showed a dose range that the company believes will restore normal KLK1 levels in CKD patients.

Encouraging early signals in estimated glomerular filtration rate, urinary albumin to creatinine ratio and other markers — a few of the key secondary endpoints along with nitric oxide and prostaglandin E2 — were also observed, DiaMedica said. 

What's Next

The favorable interim safety, tolerability and pharmacokinetic data, complemented by pharmacodynamic observations, support the advancement of DM199 to a Phase 2 clinical trial in patients with CKD, according to the biotech. 

DiaMedica said it is looking to provide full results of the study in a peer-reviewed publication and/or poster presentation.

DiaMedica shares were up 27.23% at $4.86 at the time of publication Thursday. 

Related Links:

The Daily Biotech Pulse: DiaMedica Reports Positive Data For Chronic Kidney Disease Drug, Eloxx Offering, IPO Deluge

Prevail Therapeutics IPO: What You Need To Know


Related Articles (DMAC)

View Comments and Join the Discussion!

Posted-In: Biotech News Movers Trading Ideas General Best of Benzinga

Don't Miss Any Updates!
News Directly in Your Inbox
Subscribe to:
Benzinga Premarket Activity
Get pre-market outlook, mid-day update and after-market roundup emails in your inbox.
Market in 5 Minutes
Everything you need to know about the market - quick & easy.
Fintech Focus
A daily collection of all things fintech, interesting developments and market updates.
Everything you need to know about the latest SPAC news.
Thank You

Thank you for subscribing! If you have any questions feel free to call us at 1-877-440-ZING or email us at