Big 12 foes will do battle when the No. 14 Oklahoma Sooners (4-0) meet the Iowa State Cyclones (2-2) at Gaylord Family Oklahoma Memorial Stadium in Norman, Oklahoma. Scroll down for best bets suggestions.

Best Moneyline Bet & Insights

• Score Prediction: Oklahoma 29, Iowa State 17
• Oklahoma has been favored on the moneyline a total of three times this season, and they've won all of those games.
• The Sooners have played as a moneyline favorite of -1250 or shorter in just one game this season, which they won.
• Iowa State lost the only game it has played as the underdog this season.
• The Cyclones have not entered a game this season with longer moneyline odds than +740.

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Best Over/Under Bet & Insights

• O/U Pick: Under (49.5)
• In two games this season, the Sooners and their opponents have combined to put up more than 49.5 points.
• The Cyclones have combined with their opponent to score more than 49.5 points only once this season.
• The teams combine to score 67.8 points per game, 18.3 more points than this matchup's point total.
• These teams together surrender 25 points per game, 24.5 fewer than this matchup's over/under.
• Sooners games this year have an average total of 60.5, 11.0 more points than this matchup's over/under.

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Best Against the Spread Bet & Insights

• Pick ATS: Iowa State (+19.5)
  
• The Sooners have covered the spread four times in four games.
• Oklahoma is unbeaten ATS (2-0) as a 19.5-point favorite or greater this year.
• One of the Cyclones' three games has hit the over.

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Oklahoma vs. Iowa State Game Information

• Game Date: Saturday, September 30, 2023
• Game Time: 7:00 PM ET
• Location: Norman, Oklahoma
• Venue: Gaylord Family Oklahoma Memorial Stadium
• TV Channel: Fox Sports 1
• Livestream: Stream NCAA football on Fubo!

Watch college football this season on ESPN+.

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