Safeguard Scientifics to Release Fourth Quarter and Year-End 2009 Financial Results on Thursday, March 11th

Safeguard Scientifics, Inc. (NYSE: SFE), a holding company that builds value in growth-stage life sciences and technology companies, today announced that it will release its financial results for the fourth quarter and year-ended December 31, 2009 prior to market open on Thursday, March 11, 2010.

SAFEGUARD SCIENTIFICS FOURTH QUARTER AND YEAR-END 2009 CONFERENCE CALL
Please call at least 10 minutes prior to call to register.

Date: Thursday, March 11, 2010

Time: 9:00am EST

Webcast: www.safeguard.com/earnings

Conference ID#: 55589548

Call-in Number: 877-640-9871
(International) +914-495-8549

Replay Number: 800-642-1687
(International) +706-645-9291
Replay available through April 11, 2010 at 11:59 pm ET

Podcast: www.safeguard.com/podcast
Available approximately 24 hours following the conclusion of the earnings call

Speakers: President and CEO Peter J. Boni; Senior Vice President and CFO Stephen T. Zarrilli

Format: Discussion of fourth quarter and year-end 2009 financial results followed by Q&A.

For more information please contact IR@safeguard.com.

About Safeguard Scientifics

Founded in 1953 and based in Wayne, PA, Safeguard Scientifics, Inc. (NYSE: SFE) provides growth capital for entrepreneurial and innovative life sciences and technology companies. Safeguard targets life sciences companies in Molecular and Point-of-Care Diagnostics, Medical Devices, Regenerative Medicine and Specialty Pharmaceuticals, and technology companies in Internet / New Media, Financial Services IT and Healthcare IT with capital requirements of up to $25 million. Safeguard participates in expansion financings, corporate spin-outs, management buyouts, recapitalizations, industry consolidations and early-stage financings. www.safeguard.com