AbbVie Shows Progress in Oncology Research at ASCO '16 Annual Meeting

AbbVie

, a global biopharmaceutical company, will present data from multiple clinical trials evaluating the company's portfolio of approved and investigational oncology medicines during the 52nd Annual Meeting of the American Society of Clinical Oncology (ASCO), June 3-7, in Chicago. Notably, researchers will present data from studies evaluating Venclexta™ (venetoclax), a BCL-2 inhibitor being developed by AbbVie and Genentech, a member of the Roche Group, and IMBRUVICA® (ibrutinib), an inhibitor of Bruton's tyrosine kinase (BTK), across multiple hematologic malignancies. Additionally, researchers will present data on ABT-414, an investigational antibody-drug conjugate (ADC), as monotherapy in epidermal growth factor receptor (EGFR) amplified, recurrent glioblastoma (GBM),1 an aggressive malignant primary brain tumor.2 Data on Venclexta will be featured in the "Best of ASCO" program and presented in cities across the country. "Best of ASCO" features the top abstracts, highlighting the most cutting-edge science and education from the annual meeting. "The multiple data presentations we will be making at ASCO 2016 underscore AbbVie's commitment to pursue new cancer therapy options, with the potential to make a real and remarkable impact on the lives of people affected by cancer," said Michael Severino, M.D., executive vice president of research and development and chief scientific officer, AbbVie. "AbbVie is committed to working together with the oncology research community, healthcare and clinical experts, industry peers, patients and patient advocacy groups, to discover and develop therapies with the goal of transforming the treatment of cancer." AbbVie abstracts: Venclexta™ (venetoclax) Phase 1b/2 study of venetoclax with low-dose cytarabine in treatment-naïve patients aged ≥65 years with acute myelogenous leukemia; Lin et al.; Abstract 7007; Oral Presentation; Saturday, June 4, 2016; 3-6 p.m. CDT Results of a phase 1b study of venetoclax plus decitabine or azacitidine in untreated acute myeloid leukemia patients ≥65 years ineligible for standard induction therapy; Pollyea et al.; Abstract 7009; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT with Poster Discussion Monday, June 6, 2016; 11:30 a.m.-12:45 p.m. CDT (abstract selected for "Best of ASCO" program) Phase 1 venetoclax monotherapy for relapsed/refractory multiple myeloma; Kumar et al.; Abstract 8032; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT Phase 1b venetoclax combined with bortezomib and dexamethasone in relapsed/refractory multiple myeloma; Moreau et al.; Abstract 8011; Oral Presentation; Tuesday, June 7, 2016; 9:45-11:15 a.m. CDT Safety, efficacy and immune effects of venetoclax 400 mg daily in patients with relapsed chronic lymphocytic leukemia; Davids et al.; Abstract 7527; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT Venetoclax activity in CLL patients who have relapsed after or are refractory to ibrutinib or idelalisib; Jones et al.; Abstract 7519; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT with Poster Discussion Monday, June 6, 2016; 1:15-2:45 p.m. CDT Integrated safety analysis of venetoclax monotherapy in chronic lymphocytic leukemia; Davids et al.; Abstract 7528; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT Phase 1b study of venetoclax plus R- and G-CHOP in patients with B-cell non-Hodgkin lymphoma; Zelentz et al.; Abstract 7566; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT Imbruvica® (ibrutinib) A phase 1b/2 study of ibrutinib combination therapy in selected advanced genitourinary and gastrointestinal tumors; Berlin et al.; Abstract TPS2600; Poster Session; Sunday, June 5, 2016; 8-11:30 a.m. CDT A randomized, double-blind, placebo-controlled study of ibrutinib, a Bruton Tyrosine Kinase inhibitor, with nab-paclitaxel and gemcitabine in the first-line treatment of patients with metastatic pancreatic adenocarcinoma (RESOLVE); Tempero et al.; Abstract TPS2601; Poster Session; Sunday, June 5, 2016; 8-11:30 a.m. CDT Ibrutinib (I) plus bendamustine and rituximab (BR) in previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): a 2-year follow-up of the HELIOS study; Fraser et al.; Abstract 7525; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT Sequence variants in patients with primary and acquired resistance to ibrutinib in the phase 3 MCL3001 (RAY) trial; Lenz et al.; Abstract 7570; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT Outcomes with ibrutinib by line of therapy in patients with CLL: Analyses from phase 3 data; O'Brien et al.; Abstract 7520; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT with Poster Discussion Monday, June 6, 2016; 1:15-2:45 p.m. CDT Empliciti™ (elotuzumab) Health care resource utilization (HCRU) in relapsed/refractory multiple myeloma (RRMM): results from PREAMBLE; Goldschmidt et al.; Abstract 6621; Poster Session; Saturday, June 4, 2016; 1-4:30 p.m. CDT A randomized phase 2 study of pomalidomide/dexamethasone with or without elotuzumab in patients with relapsed/refractory multiple myeloma; San Miguel et al.; Abstract TPS8066; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT ELOQUENT-2 update: Phase III study of elotuzumab plus lenalidomide/dexamethasone (ELd) vs Ld in relapsed/refractory multiple myeloma (RRMM)–Identifying responders by subset analysis; Lonial et al.; Abstract 8037; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT ABT-414 Efficacy of a novel antibody-drug conjugate (ADC), ABT-414, as monotherapy in epidermal growth factor receptor (EGFR) amplified, recurrent glioblastoma (GBM); van den Bent et al.; Abstract 2542; Poster Session; Sunday, June 5, 2016; 8-11:30 a.m. CDT Duvelisib FRESCO: A phase 2, randomized study of duvelisib plus rituximab vs R-CHOP in patients with relapsed/refractory follicular lymphoma who have progressed within 24 months of receiving an alkylator-based chemotherapy regimen; Fowler et al.; Abstract TPS7578; Poster Session; Monday, June 6, 2016; 8-11:30 a.m. CDT Preliminary safety, pharmacokinetics, and pharmacodynamics of duvelisib plus rituximab or obinutuzumab in subjects with previously untreated CD20+ follicular lymphoma; Casulo et al.; Abstract e19052; Publication Veliparib Veliparib (ABT-888) extended release formulations: A phase 1 study on safety, pharmacokinetics (PK), and bioavailability in patients with advanced solid tumors; Werner et al.; Abstract 2579; Poster Session; Sunday, June 5, 2016; 8-11:30 a.m. CDT ABBV-399 Phase 1, open-label, dose-escalation and expansion study of ABBV-399, an antibody drug conjugate (ADC) targeting c-Met, in patients (pts) with advanced solid tumors; Strickler et al.; Abstract 2510; Poster Session; Sunday, June 5, 2016; 8-11:30 a.m. CDT with Poster Discussion Sunday, June 5, 2016; 11:30 a.m.-12:45 p.m. CDT ABT-165 Phase 1, open-label, dose-escalation and expansion study of ABT-165, a dual variable domain immunoglobulin (DVD-Ig) targeting both DLL4 and VEGF, in patients (pts) with advanced solid tumors; Gordon et al.; Abstract 2507; Oral Presentation; Monday, June 6, 2016; 8-11 a.m. CDT The ASCO 2016 Annual Meeting abstracts are available at http://am.asco.org/abstracts.