Benzinga's Top #PreMarket Gainers

shares climbed 6.06 percent to $18.56 in pre-market trading after the company reported a narrower-than-expected loss for its first quarter.

shares rose 2.46 percent to $12.50 in pre-market trading. AstraZeneca and Ironwood reported positive top-line data from Phase III IBS-C trial designed to support linaclotide approval in China

gained 0.56 percent to $7.21 in pre-market trading. Craig-Hallum upgraded Fuel Systems Solutions from Hold to Buy and lowered the price target from $11.00 to $10.00.

shares climbed 0.56 percent to $16.09 in pre-market trading after the company announced the departure of CEO Antony Jenkins.

shares rose 0.23 percent to $64.30 in pre-market trading after dropping 4.25 percent on Tuesday.