Lion Biotechnologies Announces Publication of Data from Study of Metastatic Cervical Cancer Patients Treated with HPV

Lion Biotechnologies, Inc.

, a biotechnology company that is developing novel cancer immunotherapies based on tumor-infiltrating lymphocytes (TIL), today announced that data from a metastatic cervical cancer study conducted by the National Cancer Institute (NCI) was published in the Journal of Clinical Oncology in an article titled "Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus-Targeted Tumor-Infiltrating T Cells". Data from the trial showed objective responses, including durable, complete regressions, in patients after a single infusion of HPV-TIL. The trial was designed to determine if the infusion of human papillomavirus tumor-infiltrating lymphocytes (HPV-TIL) could induce regression of advanced HPV-positive cancers. Of the nine metastatic cervical cancer patients who were enrolled and treated with HPV-TIL, three patients experienced objective tumor responses, two of whom experienced complete, ongoing remissions of 22 and 15 months, respectively. The other patient demonstrated a partial response of three months. "We are pleased to see the results of this trial, which demonstrate potential efficacy of TIL treatment in metastatic cervical cancer, a notoriously difficult-to-treat cancer in women," said Elma Hawkins, PhD, Lion's president and chief executive officer. "We recently amended our CRADA with the NCI to include technologies based on the HPV-TIL research. With these technologies, we look forward to expanding our clinical programs and developing new treatment options for patients with cervical cancer and other solid tumors."