Aldeyra Therapeutics Announces First Patient Enrolled in Sjogren-Larsson Syndrome Phase II Clinical Trial

Aldeyra Therapeutics, Inc.

(Aldeyra), a biotechnology company focused on the development of products to treat diseases related to free aldehydes, today announced that it has enrolled the first patient in its Phase II clinical trial of NS2 for the treatment of Sjögren-Larsson Syndrome (SLS). The trial is being held at the University of Nebraska University Medical Center, the leading treatment center in the United States for SLS. Todd C. Brady, M.D., Ph.D., President and CEO of Aldeyra, commented, "We are excited to have the first patient enrolled in our Phase II clinical trial of NS2 for the treatment of Sjögren-Larsson Syndrome. This is an important step toward achieving clinical data and demonstrating the efficacy and safety of our novel aldehyde trap in a rare disease with no FDA-approved therapy. We anticipate announcing preliminary data by the end of 2015 and look forward to providing these results." A synopsis of the trial has been submitted to www.clinicaltrials.gov and is expected to be available within 21 days. About NS2 NS2 is an aldehyde-binding small molecule based on an innovative platform technology focused on trapping free aldehydes, which are toxic and pro-inflammatory mediators of numerous diseases. By decreasing aldehyde load, NS2 may mitigate excessive inflammation and address diseases where aldehydes are thought to mediate pathology. About Sjögren-Larsson Syndrome Sjögren-Larsson Syndrome (SLS) is a rare disease caused by mutations in fatty acid aldehyde dehydrogenase, leading to elevated fatty aldehyde levels that are thought to contribute to severe ichthyosis (scaly, thickened, dry skin), neurological disorders, and retinal disease.