Benzinga's Top #PreMarket Gainers

Synergy Pharmaceuticals

shares jumped 13.14% to $3.10 in pre-market trading after the company presented positive Phase 2b study results for Plecanatide in patients with irritable bowel syndrome with constipation. Illumina

shares jumped 8.60% to $178.62 in pre-market trading after the company reported upbeat quarterly earnings and raised its earnings guidance for the full year. Harley-Davidson

shares rose 7.74% to $62.90 in pre-market trading after the company posted better-than-expected earnings for the third quarter. Inovio Pharmaceuticals

gained 6.48% to $12.98 after the company reported that the DARPA has awarded $12.2 million for a collaborative study that will be conducted by scientists from the Perelman School of Medicine at the University of Pennsylvania; Inovio Pharmaceuticals; and MedImmune.