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Ophthotech (NASDAQ: OPHT) soared 23.97% to $39.00 in the pre-market trading after the company reported that it has entered into an ex-US licensing and commercialization deal with Novartis Pharmaceuticals.

NewLead Holdings (NASDAQ: NEWL) shares jumped 12.82% to $2.20 after surging 209.72% on Monday.

Dendreon (NASDAQ: DNDN) shares jumped 10.28% to $2.36 in pre-market trading after the company announced the presentation of PROVENGE ProACT and IMPACT studies data.

Clovis Oncology (NASDAQ: CLVS) shares climbed 7.45% to $61.00 in the pre-market trading session after the company reported that it has received breakthrough therapy designation for CO-1686.

AstraZeneca PLC (NYSE: AZN) shares gained 1.95% to $72.02 in pre-market trading on investor call for talks with Pfizer (NYSE: PFE).

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