Receptos to Initiate Phase 3 Trial of RPC1063 in Relapsing MS

Receptos

announced today that the Company has completed a pre-planned interim analysis of the Phase 2 portion of RADIANCE, its Phase 2/3 trial of RPC1063 in relapsing multiple sclerosis (RMS). The Data Monitoring Committee (DMC) reviewed data from the interim analysis of the study and approved continuation of the Phase 2 portion as well as initiation of the Phase 3 portion of the study. The results continue to support the RPC1063 differentiation profile and are consistent with data from prior RPC1063 studies. Based on the results of the interim analysis and the DMC recommendation, Receptos will initiate the Phase 3 portion of RADIANCE. Top-line results of the Phase 2 portion of the study continue to be expected in mid-2014.  The interim analysis focused on several potential product attributes that may be important for differentiation from other S1P receptor modulators on the market or in development. The following preliminary observations of the interim data were made with regard to key aspects of the product profile: The overall adverse event profile appears relatively balanced between RPC1063