Benzinga's Top #PreMarket Losers

Celldex Therapeutics

dipped 9.47% to $25.63 in the pre-market session after the company reported positive Phase 2 rindopepimut data in patients with recurrent glioblastoma. J. C. Penney Company

dipped 2.59% to $8.64. J.C. Penney will leave the Standard & Poor's 500 index. The retailer will be replaced by Allegion Plc in the index. JetBlue Airways

shares dropped 2.09% to $8.90 in pre-market trading after Raymond James downgraded the stock from Market Perform to Underperform. Qiagen NV

shares fell 1.61% to $23.18 in the pre-market trading. Qiagen's PEG ratio is 3.34.