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Chelsea Therapeutics International (NASDAQ: CHTP) added 111.63% to $1.62 in the pre-market session. Chelsea Therapeutics received written guidance from the Director of the Office of New Drugs at the FDA for a Northera(TM) (Droxidopa) New Drug Application resubmission with study 306B.

Netspend Holdings (NASDAQ: NTSP) moved up 29.05% to $15.86 in the pre-market session. Total System Services (NYSE: TSS) announced its plans to buy NetSpend for around $1.4 billion in cash.

Demand Media (NYSE: DMD) soared 17.98% to $9.25 in the pre-market trading. Demand Media reported that its board is exploring a plan to split the company into two separate publicly traded firms.

OfficeMax (NYSE: OMX) surged 15.00% to $14.95 in the pre-market session. Office Depot (NYSE: ODP) agreed to acquire OfficeMax in an all-stock deal.

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