Benzinga's Top Pre-Market Gainers

Chelsea Therapeutics International

added 111.63% to $1.62 in the pre-market session. Chelsea Therapeutics received written guidance from the Director of the Office of New Drugs at the FDA for a Northera(TM) (Droxidopa) New Drug Application resubmission with study 306B. Netspend Holdings

moved up 29.05% to $15.86 in the pre-market session. Total System Services

announced its plans to buy NetSpend for around $1.4 billion in cash. Demand Media

soared 17.98% to $9.25 in the pre-market trading. Demand Media reported that its board is exploring a plan to split the company into two separate publicly traded firms. OfficeMax

surged 15.00% to $14.95 in the pre-market session. Office Depot

agreed to acquire OfficeMax in an all-stock deal.