Rexahn Pharmaceuticals Publishes New Preclinical Data for Quinoxalinyl-Piperazine Compounds
Rexahn Pharmaceuticals, Inc. (NYSE: RNN) today announced the publication of preclinical results for RX-5902 in Bioorganic & Medicinal Chemistry [20:1303-1309, 2012] titled, “Synthesis, anticancer activity and pharmacokinetic analysis of 1-[(substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives.”
In the study, various new quinoxalinyl-piperazine derivatives were shown to have excellent anti-proliferative activity against different human cancer cells, and some selected compounds showed excellent pharmacokinetic properties in rats. In particular, RX-5902 exhibited desirable pharmacokinetic properties – such as in oral bioavailability, half-life, and plasma concentration - supporting its continued development as an orally deliverable potent anti-cancer drug.
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