Idera Pharmaceuticals Presents Data in Preclinical Models of Lymphoma on IMO-4200, a Dual Agonist of TLRs 7 and 8

Idera Pharmaceuticals

today announced that it presented new data showing that IMO-4200, a dual agonist of Toll-like receptor 7 and TLR8, in combination with approved cancer treatments increased antitumor activity in preclinical models of lymphoma. The presentation by Idera scientists, entitled “IMO-4200, a novel TLR7 and TLR8 dual agonist, enhances antitumor effect of ofatumumab, rituximab and cytotoxics in preclinical models of hematological malignancies”, abstract number 3724, was made at the 53rd annual meeting of the American Society for Hematology being held in San Diego, California December 11-13, 2011. “The data presented show that IMO-4200 provides a novel scientific rationale for the targeted immunotherapy of hematological malignancies,” said Nicola La Monica, Ph.D., VP of Biology of Idera Pharmaceuticals. “IMO-4200 has shown to potentiate the anti-cancer activity of a broad range of approved agents, including rituximab, bortezomib and ofatumumab, in preclinical models of lymphoma.”